Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels - PubMed (original) (raw)
. 2010 Nov;95(11):5037-44.
doi: 10.1210/jc.2009-2566. Epub 2010 Aug 18.
Affiliations
- PMID: 20719836
- DOI: 10.1210/jc.2009-2566
Free article
Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels
Ana B Crujeiras et al. J Clin Endocrinol Metab. 2010 Nov.
Free article
Abstract
Context: Appetite-related hormones may play an important role in weight regain after obesity therapy.
Objective: Our objective was to investigate the potential involvement of ghrelin, leptin, and insulin plasma levels in weight regain after a therapeutic hypocaloric diet.
Design: A group of obese/overweight volunteers (49 women and 55 men; 35 ± 7 yr; 30.7 ± 2.4 kg/m(2)) followed an 8-wk hypocaloric diet (-30% energy expenditure) and were evaluated again 32 wk after treatment. Body weight as well as plasma fasting ghrelin, leptin, and insulin concentrations were measured at three points (wk 0, 8, and 32).
Results: After the 8-wk hypocaloric diet, the average weight loss was -5.0 ± 2.2% (P < 0.001). Plasma leptin and insulin concentrations decreased significantly, whereas ghrelin levels did not markedly change. In the group regaining more than 10% of the weight loss, leptin levels were higher (P < 0.01), whereas ghrelin levels were lower (P < 0.05). No differences were observed in insulin levels. Weight regain at wk 32 was negatively correlated with ghrelin and positively associated with leptin levels at baseline (wk 0) and endpoint (wk 8). These outcomes showed a gender-specific influence, being statistically significant among men for ghrelin and between women for leptin. Moreover, a decrease in ghrelin after an 8-wk hypocaloric diet was related to an increased risk for weight regain (odds ratio = 3.109; P = 0.008) whereas a greater reduction in leptin (odds ratio = 0.141; P = 0.001) was related to weight-loss maintenance.
Conclusions: Subjects with higher plasma leptin and lower ghrelin levels at baseline could be more prone to regain lost weight, and hormones levels could be proposed as biomarkers for predicting obesity-treatment outcomes.
Similar articles
- Pre-treatment circulating leptin/ghrelin ratio as a non-invasive marker to identify patients likely to regain the lost weight after an energy restriction treatment.
Crujeiras AB, Díaz-Lagares A, Abete I, Goyenechea E, Amil M, Martínez JA, Casanueva FF. Crujeiras AB, et al. J Endocrinol Invest. 2014 Feb;37(2):119-26. doi: 10.1007/s40618-013-0004-2. Epub 2014 Jan 9. J Endocrinol Invest. 2014. PMID: 24497210 Clinical Trial. - Role of baseline leptin and ghrelin levels on body weight and fat mass changes after an energy-restricted diet intervention in obese women: effects on energy metabolism.
Labayen I, Ortega FB, Ruiz JR, Lasa A, Simón E, Margareto J. Labayen I, et al. J Clin Endocrinol Metab. 2011 Jun;96(6):E996-1000. doi: 10.1210/jc.2010-3006. Epub 2011 Apr 6. J Clin Endocrinol Metab. 2011. PMID: 21470990 - Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature.
Strohacker K, McCaffery JM, MacLean PS, Wing RR. Strohacker K, et al. Int J Obes (Lond). 2014 Mar;38(3):388-96. doi: 10.1038/ijo.2013.118. Epub 2013 Jun 26. Int J Obes (Lond). 2014. PMID: 23801147 Free PMC article. Review. - Attenuating the Biologic Drive for Weight Regain Following Weight Loss: Must What Goes Down Always Go Back Up?
Melby CL, Paris HL, Foright RM, Peth J. Melby CL, et al. Nutrients. 2017 May 6;9(5):468. doi: 10.3390/nu9050468. Nutrients. 2017. PMID: 28481261 Free PMC article. Review.
Cited by
- Nutrition targeting by food timing: time-related dietary approaches to combat obesity and metabolic syndrome.
Sofer S, Stark AH, Madar Z. Sofer S, et al. Adv Nutr. 2015 Mar 13;6(2):214-23. doi: 10.3945/an.114.007518. Print 2015 Mar. Adv Nutr. 2015. PMID: 25770260 Free PMC article. Review. - Thyroid Function Alteration in Obesity and the Effect of Bariatric Surgery.
Cordido M, Juiz-Valiña P, Urones P, Sangiao-Alvarellos S, Cordido F. Cordido M, et al. J Clin Med. 2022 Feb 28;11(5):1340. doi: 10.3390/jcm11051340. J Clin Med. 2022. PMID: 35268429 Free PMC article. Review. - Interplay of atherogenic factors, protein intake and betatrophin levels in obese-metabolic syndrome patients treated with hypocaloric diets.
Crujeiras AB, Zulet MA, Abete I, Amil M, Carreira MC, Martínez JA, Casanueva FF. Crujeiras AB, et al. Int J Obes (Lond). 2016 Mar;40(3):403-10. doi: 10.1038/ijo.2015.206. Epub 2015 Oct 7. Int J Obes (Lond). 2016. PMID: 26443337 - Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats.
Ezquerro S, Méndez-Giménez L, Becerril S, Moncada R, Valentí V, Catalán V, Gómez-Ambrosi J, Frühbeck G, Rodríguez A. Ezquerro S, et al. Sci Rep. 2016 Dec 23;6:39942. doi: 10.1038/srep39942. Sci Rep. 2016. PMID: 28008992 Free PMC article. - How to estimate fat mass in overweight and obese subjects.
Donini LM, Poggiogalle E, Del Balzo V, Lubrano C, Faliva M, Opizzi A, Perna S, Pinto A, Rondanelli M. Donini LM, et al. Int J Endocrinol. 2013;2013:285680. doi: 10.1155/2013/285680. Epub 2013 Apr 10. Int J Endocrinol. 2013. PMID: 23662101 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical