Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009 - PubMed (original) (raw)
. 2010 Oct;65(10):2116-8.
doi: 10.1093/jac/dkq279. Epub 2010 Aug 20.
Affiliations
- PMID: 20729241
- DOI: 10.1093/jac/dkq279
Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009
Ahmed Bueid et al. J Antimicrob Chemother. 2010 Oct.
Abstract
Objectives: Resistance to azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in some locations. Here we update our previous experience with data from 2008-09.
Methods: We tested all A. fumigatus isolates submitted to the Mycology Reference Centre Manchester in 2008 and 2009 for susceptibility to itraconazole, voriconazole and posaconazole. We undertook CYP51A sequencing for most of the azole-resistant isolates.
Results: Of 230 isolates, 64 (28%) were azole resistant. In 2008 and 2009, 14% and 20% of patients had resistant isolates, respectively. During this period 62 of 64 (97%) were itraconazole resistant, 2 of 64 (3%) were only voriconazole resistant and 78% of cases were multi-azole resistant. Forty-three percent of isolates did not carry a cyp51A mutation (previously the most common azole resistance mechanism), indicating that other mechanisms must be responsible and are increasing in frequency.
Conclusions: Azole resistance is evolving and growing in frequency. Established and novel mechanisms may be responsible.
Similar articles
- Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.
Chowdhary A, Kathuria S, Randhawa HS, Gaur SN, Klaassen CH, Meis JF. Chowdhary A, et al. J Antimicrob Chemother. 2012 Feb;67(2):362-6. doi: 10.1093/jac/dkr443. Epub 2011 Oct 25. J Antimicrob Chemother. 2012. PMID: 22028200 - Aspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole.
Lescar J, Meyer I, Akshita K, Srinivasaraghavan K, Verma C, Palous M, Mazier D, Datry A, Fekkar A. Lescar J, et al. J Antimicrob Chemother. 2014 Dec;69(12):3244-7. doi: 10.1093/jac/dku316. Epub 2014 Aug 13. J Antimicrob Chemother. 2014. PMID: 25125676 - First determination of azole resistance in Aspergillus fumigatus strains carrying the TR34/L98H mutations in Turkey.
Özmerdiven GE, Ak S, Ener B, Ağca H, Cilo BD, Tunca B, Akalın H. Özmerdiven GE, et al. J Infect Chemother. 2015 Aug;21(8):581-6. doi: 10.1016/j.jiac.2015.04.012. Epub 2015 May 14. J Infect Chemother. 2015. PMID: 26048062 - Azole resistant Aspergillus fumigatus: an emerging problem.
Lelièvre L, Groh M, Angebault C, Maherault AC, Didier E, Bougnoux ME. Lelièvre L, et al. Med Mal Infect. 2013 Apr;43(4):139-45. doi: 10.1016/j.medmal.2013.02.010. Epub 2013 Apr 4. Med Mal Infect. 2013. PMID: 23562488 Review. - Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms.
Chowdhary A, Sharma C, Hagen F, Meis JF. Chowdhary A, et al. Future Microbiol. 2014;9(5):697-711. doi: 10.2217/fmb.14.27. Future Microbiol. 2014. PMID: 24957095 Review.
Cited by
- Review of the Novel Investigational Antifungal Olorofim.
Wiederhold NP. Wiederhold NP. J Fungi (Basel). 2020 Jul 30;6(3):122. doi: 10.3390/jof6030122. J Fungi (Basel). 2020. PMID: 32751765 Free PMC article. Review. - Inducible Cell Fusion Permits Use of Competitive Fitness Profiling in the Human Pathogenic Fungus Aspergillus fumigatus.
Macdonald D, Thomson DD, Johns A, Contreras Valenzuela A, Gilsenan JM, Lord KM, Bowyer P, Denning DW, Read ND, Bromley MJ. Macdonald D, et al. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e01615-18. doi: 10.1128/AAC.01615-18. Print 2019 Jan. Antimicrob Agents Chemother. 2018. PMID: 30397071 Free PMC article. - Molecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study).
Alastruey-Izquierdo A, Alcazar-Fuoli L, Rivero-Menéndez O, Ayats J, Castro C, García-Rodríguez J, Goterris-Bonet L, Ibáñez-Martínez E, Linares-Sicilia MJ, Martin-Gomez MT, Martín-Mazuelos E, Pelaez T, Peman J, Rezusta A, Rojo S, Tejero R, Anza DV, Viñuelas J, Zapico MS, Cuenca-Estrella M; the FILPOP2 Project from GEMICOMED (SEIMC) and REIPI. Alastruey-Izquierdo A, et al. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00358-18. doi: 10.1128/AAC.00358-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29941643 Free PMC article. - hapE and hmg1 Mutations Are Drivers of _cyp51A_-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate.
Souza ACO, Ge W, Wiederhold NP, Rybak JM, Fortwendel JR, Rogers PD. Souza ACO, et al. Microbiol Spectr. 2023 Jun 15;11(3):e0518822. doi: 10.1128/spectrum.05188-22. Epub 2023 May 4. Microbiol Spectr. 2023. PMID: 37140376 Free PMC article. - Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens.
Novak-Frazer L, Anees-Hill SP, Hassan D, Masania R, Moore CB, Richardson MD, Denning DW, Rautemaa-Richardson R. Novak-Frazer L, et al. J Antimicrob Chemother. 2020 Dec 1;75(12):3501-3509. doi: 10.1093/jac/dkaa357. J Antimicrob Chemother. 2020. PMID: 32862231 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical