Antigen processing and presentation in vivo: the microenvironment as a crucial factor - PubMed (original) (raw)
Antigen processing and presentation in vivo: the microenvironment as a crucial factor
N van Rooijen. Immunol Today. 1990 Dec.
Abstract
Antigen processing and presentation in vitro is an increasingly well understood phenomenon. However, in vivo, a large number of variables conspire to obscure and confuse. In this article, Nico van Rooijen attempts to bring order to events that occur in the spleen after antigenic challenge: starting with the large body of reliable in vitro data he incorporates information on splenic anatomy, cell trafficking and the cellular microenvironment to arrive at a physiological model for antigen handling in vivo.
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