A structural overview of the PDI family of proteins - PubMed (original) (raw)

Review

. 2010 Oct;277(19):3924-36.

doi: 10.1111/j.1742-4658.2010.07793.x. Epub 2010 Aug 26.

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• PMID: 20796029
• DOI: 10.1111/j.1742-4658.2010.07793.x

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Review

A structural overview of the PDI family of proteins

Guennadi Kozlov et al. FEBS J. 2010 Oct.

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Abstract

Protein disulfide isomerases (PDIs) are enzymes that mediate oxidative protein folding in the endoplasmic reticulum. Understanding of PDIs has historically been hampered by lack of structural information. Over the last several years, partial and full-length PDI structures have been solved at an increasing rate. Analysis of the structures reveals common features shared by several of the best known PDI family members, and also unique features related to substrate and partner binding sites. These exciting breakthroughs provide a deeper understanding of the mechanisms of oxidative protein folding in cells.

© 2010 The Authors Journal compilation © 2010 FEBS.

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