Pericardial fat is independently associated with human atrial fibrillation - PubMed (original) (raw)
. 2010 Aug 31;56(10):784-8.
doi: 10.1016/j.jacc.2010.03.071.
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- PMID: 20797492
- DOI: 10.1016/j.jacc.2010.03.071
Free article
Pericardial fat is independently associated with human atrial fibrillation
M Obadah Al Chekakie et al. J Am Coll Cardiol. 2010.
Free article
Abstract
Objectives: The purpose of this study was to investigate the association between atrial fibrillation (AF) and pericardial fat.
Background: Pericardial fat is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with AF, but the relationship between AF and pericardial fat is unknown.
Methods: Pericardial fat volume was measured using computed tomography in 273 patients: 76 patients in sinus rhythm, 126 patients with paroxysmal AF, and 71 patients with persistent AF.
Results: Patients with AF had significantly more pericardial fat compared with patients in sinus rhythm (101.6 +/- 44.1 ml vs. 76.1 +/- 36.3 ml, p < 0.001). Pericardial fat volume was significantly larger in paroxysmal AF compared with the sinus rhythm group (93.9 +/- 39.1 ml vs. 76.1 +/- 36.3 ml, p = 0.02). Persistent AF patients had a significantly larger pericardial fat volume compared with paroxysmal AF (115.4 +/- 49.3 ml vs. 93.9 +/- 39.1 ml, p = 0.001). Pericardial fat volume was associated with paroxysmal AF (odds ratio: 1.11; 95% confidence interval: 1.01 to 1.23, p = 0.04) and persistent AF (odds ratio: 1.18, 95% confidence interval: 1.05 to 1.33, p = 0.004), and this association was completely independent of age, hypertension, sex, left atrial enlargement, valvular heart disease, left ventricular ejection fraction, diabetes mellitus, and body mass index.
Conclusions: Pericardial fat volume is highly associated with paroxysmal and persistent AF independent of traditional risk factors including left atrial enlargement. Whether pericardial fat plays a role in the pathogenesis of AF requires future investigation.
Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Comment in
- Periatrial epicardial fat, local pro- and anti-inflammatory balance, and atrial fibrillation.
Liu T, Li G. Liu T, et al. J Am Coll Cardiol. 2011 Mar 8;57(10):1249; author reply 1249. doi: 10.1016/j.jacc.2010.09.068. J Am Coll Cardiol. 2011. PMID: 21371644 No abstract available.
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