Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity - PubMed (original) (raw)

. 2010 Nov;137(2):288-95.

doi: 10.1016/j.clim.2010.07.012.

Qiang Shu, Lifen Gao, Nan Hou, Di Zhao, Xiao Liu, Xiaoning Zhang, Liyun Xu, Xuetian Yue, Faliang Zhu, Chun Guo, Xiaohong Liang, Chunhong Ma

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Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity

Ying Liu et al. Clin Immunol. 2010 Nov.

Abstract

Tim-3 has been reported as an important regulatory molecule and plays a pivotal role in several autoimmunity diseases. Here, we demonstrated the increased expression of Tim-3 on peripheral CD4(+) T, CD8(+) T, NKT cells and monocytes from RA patients compared to those from healthy controls. Percentage of Tim-3(+) cells in peripheral blood mononuclear cells (PBMCs) showed an inverse correlation with disease activity score 28 (DAS28) and plasma TNF-α level. Similar negative correlations were found between disease activity and Tim-3 levels on CD4(+) T, CD8(+) T and NKT cells. Consistently, Tim-3 expression on CD3(+) T cells was further increased in patients with disease remission after treatment. Tim-3 expression on CD8(+) T and NKT cells negatively correlates with plasma TNF-α. Our results suggest that Tim-3 might participate in the proceeding of RA by its negative regulation on various T cell subsets. Tim-3 might be a potential new marker for assessing severity of RA.

Copyright © 2010 Elsevier Inc. All rights reserved.

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