Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy - PubMed (original) (raw)
Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy
Maryam Darabi et al. Gynecol Endocrinol. 2011 Sep.
Free article
Abstract
Objective: The ATP binding cassette A1 (ABCA1) is a key participant in the reverse cholesterol process whereby mediates cholesterol efflux directly to HDL particles. The aim of this study was to investigate whether long-term treatment with conventional hormone replacement therapy (HRT) in post-menopausal women could affect their leukocytes ABCA1 expression. Changes in various serum lipids and lipoprotein fractions were also investigated.
Material and methods: A total of 60 non-obese normolipidaemic post-menopausal women treated with oral oestrogen together with progestin therapy for 3 months were selected. Leukocytes ABCA1 gene expression and serum lipid and lipoprotein concentrations were measured at the start and end of the HRT.
Results: HRT led to significant increases in HDL cholesterol (P = 0.001) and apoA-I (P = 0.046) and significant decrease in apoB (P = 0.049) and LDL cholesterol (P = 0.022) when compared with the baseline levels. Analysis of leukocytes ABCA1 mRNA showed a significant increase in ABCA1 gene expression after HRT (P = 0.001). There was also a significant inverse association (r = -0.28, P = 0.03) between ABCA1 gene expression and log TG/HDL cholesterol changes related to HRT.
Conclusion: The beneficial cardiovascular effects of HRT could be explained, at least in part, by increasing the ABCA1 gene expression.
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