The efficacy of intranasal interferon alpha-2a in respiratory syncytial virus infection in volunteers - PubMed (original) (raw)

Clinical Trial

The efficacy of intranasal interferon alpha-2a in respiratory syncytial virus infection in volunteers

P G Higgins et al. Antiviral Res. 1990 Jul.

Abstract

In a double-blind, placebo-controlled study, self-administered intranasal interferon alpha-2a or placebo was given both before and after challenge with respiratory syncytial virus. The incidence of colds and the severity of signs and symptoms were reduced in those receiving interferon alpha-2a as compared with those given placebo. In a further double-blind, placebo-controlled study, self-administered interferon alpha-2a or placebo was given only to those volunteers who developed colds following challenge with respiratory syncytial virus. There was no evidence that interferon alpha-2a reduced the severity of the signs and symptoms or shortened the duration of the illness. The similarity of these results to the effect of interferon alpha-2a in rhinovirus infections in volunteers is discussed.

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