Role of heme oxygenase-1 in transplantation - PubMed (original) (raw)
Review
. 2010 Nov;23(11):1071-81.
doi: 10.1111/j.1432-2277.2010.01158.x. Epub 2010 Aug 31.
Affiliations
- PMID: 20819190
- DOI: 10.1111/j.1432-2277.2010.01158.x
Free article
Review
Role of heme oxygenase-1 in transplantation
Robert Öllinger et al. Transpl Int. 2010 Nov.
Free article
Abstract
Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme catabolism that converts heme to Fe++, carbon monoxide and biliverdin. HO-1 acts anti-inflammatory and modulates apoptosis in many pathological conditions. In transplantation, HO-1 is overexpressed in organs during brain death, when undergoing ischemic damage and rejection. However, intentionally induced, it ameliorates pathological processes like ischemia reperfusion injury, allograft, xenograft or islet rejection, facilitates donor specific tolerance and alleviates chronic allograft changes. We herein consistently summarize the huge amount of data on HO-1 and transplantation that have been generated in multiple laboratories during the last 15years and suggest possible clinical implications and applications for the near future.
© 2010 The Authors. Transplant International © 2010 European Society for Organ Transplantation.
Similar articles
- Therapeutic applications of bilirubin and biliverdin in transplantation.
Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH. Ollinger R, et al. Antioxid Redox Signal. 2007 Dec;9(12):2175-85. doi: 10.1089/ars.2007.1807. Antioxid Redox Signal. 2007. PMID: 17919067 Review. - Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction.
Camara NO, Soares MP. Camara NO, et al. Free Radic Biol Med. 2005 Feb 15;38(4):426-35. doi: 10.1016/j.freeradbiomed.2004.11.019. Free Radic Biol Med. 2005. PMID: 15649645 Review. - Heme oxygenase-1 in organ transplantation.
Soares MP, Bach FH. Soares MP, et al. Front Biosci. 2007 Sep 1;12:4932-45. doi: 10.2741/2439. Front Biosci. 2007. PMID: 17569621 Review. - Heme oxygenase-1 ameliorates ischemia/reperfusion injury by targeting dendritic cell maturation and migration.
Kotsch K, Martins PN, Klemz R, Janssen U, Gerstmayer B, Dernier A, Reutzel-Selke A, Kuckelkorn U, Tullius SG, Volk HD. Kotsch K, et al. Antioxid Redox Signal. 2007 Dec;9(12):2049-63. doi: 10.1089/ars.2007.1801. Antioxid Redox Signal. 2007. PMID: 17854277 - Heme oxygenase-1 expression in disease states.
Deshane J, Wright M, Agarwal A. Deshane J, et al. Acta Biochim Pol. 2005;52(2):273-84. Epub 2005 May 31. Acta Biochim Pol. 2005. PMID: 15933765 Review.
Cited by
- Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly?
Lundvig DM, Immenschuh S, Wagener FA. Lundvig DM, et al. Front Pharmacol. 2012 May 7;3:81. doi: 10.3389/fphar.2012.00081. eCollection 2012. Front Pharmacol. 2012. PMID: 22586396 Free PMC article. - Justification of specific genetic modifications in pigs for clinical organ xenotransplantation.
Cooper DKC, Hara H, Iwase H, Yamamoto T, Li Q, Ezzelarab M, Federzoni E, Dandro A, Ayares D. Cooper DKC, et al. Xenotransplantation. 2019 Jul;26(4):e12516. doi: 10.1111/xen.12516. Epub 2019 Apr 15. Xenotransplantation. 2019. PMID: 30989742 Free PMC article. Review. - Generation and characterization of human heme oxygenase-1 transgenic pigs.
Yeom HJ, Koo OJ, Yang J, Cho B, Hwang JI, Park SJ, Hurh S, Kim H, Lee EM, Ro H, Kang JT, Kim SJ, Won JK, O'Connell PJ, Kim H, Surh CD, Lee BC, Ahn C. Yeom HJ, et al. PLoS One. 2012;7(10):e46646. doi: 10.1371/journal.pone.0046646. Epub 2012 Oct 5. PLoS One. 2012. PMID: 23071605 Free PMC article. - Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death.
Yurcisin BM, Davison TE, Bibbs SM, Collins BH, Stamler JS, Reynolds JD. Yurcisin BM, et al. Ann Surg. 2013 May;257(5):971-7. doi: 10.1097/SLA.0b013e3182822c52. Ann Surg. 2013. PMID: 23360919 Free PMC article. - Association between HO‑1 gene promoter polymorphisms and diseases (Review).
Ma LL, Sun L, Wang YX, Sun BH, Li YF, Jin YL. Ma LL, et al. Mol Med Rep. 2022 Jan;25(1):29. doi: 10.3892/mmr.2021.12545. Epub 2021 Nov 29. Mol Med Rep. 2022. PMID: 34841438 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical