Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4 - PubMed (original) (raw)
. 2010 Nov 7;46(41):7754-6.
doi: 10.1039/c0cc02913k. Epub 2010 Sep 8.
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- PMID: 20830376
- DOI: 10.1039/c0cc02913k
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Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4
Markus Seitz et al. Chem Commun (Camb). 2010.
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Abstract
A helical tyrosine-sulfated epitope in CCR5 that is recognized by the human immunodeficiency virus type-1 envelope glycoprotein gp120 in its CD4-induced conformation can be mimicked structurally by a cyclic β-hairpin peptide containing two sulfated tyrosine residues at positions i and i + 2 along one β-strand.
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