Saponins as cytotoxic agents: a review - PubMed (original) (raw)

Saponins as cytotoxic agents: a review

Irma Podolak et al. Phytochem Rev. 2010 Sep.

Abstract

Saponins are natural glycosides which possess a wide range of pharmacological properties including cytotoxic activity. In this review, the recent studies (2005-2009) concerning the cytotoxic activity of saponins have been summarized. The correlations between the structure and the cytotoxicity of both steroid and triterpenoid saponins have been described as well as the most common mechanisms of action.

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Figures

Fig. 1

Chemical structures of polyphyllin D (1), methyl protodioscin (2), albizoside C (3) and saponin PE (4)

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References

1. 1. Abe H, Konishi H, Komiya H, et al. Effects of saikosaponins on biological membranes. Planta Med. 1981;42:356–363. - PubMed
2. 1. Acharya D, Mitaine-Offer A-C, Kaushik N, et al. Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum. J Nat Prod. 2009;72:177–181. - PubMed
3. 1. Ahmed WS, Mohamed MA, El-Dib RA, et al. New triterpene saponins from Duranta repens Linn. and their cytotoxic activity. Molecules. 2009;14:1952–1965. - PMC - PubMed
4. 1. Avilov SA, Silchenko AS, Antonov AS, et al. Synaptosides A and A1, triterpene glycosides from the sea cucumber Synapta maculata containing 3-O-methylglucuronic acid and their cytotoxic activity against tumor cells. J Nat Prod. 2008;71:525–531. - PubMed
5. 1. Bachran C, Sutherland M, Heisler I, et al. The saponin-mediated enhanced uptake of targeted saporin-based drugs is strongly dependent on the saponin structure. Exp Biol Med. 2006;231:412–420. - PubMed

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