Oxygen homeostasis - PubMed (original) (raw)

Review

. 2010 May-Jun;2(3):336-361.

doi: 10.1002/wsbm.69.

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• PMID: 20836033
• DOI: 10.1002/wsbm.69

Review

Oxygen homeostasis

Gregg L Semenza. Wiley Interdiscip Rev Syst Biol Med. 2010 May-Jun.

Abstract

Metazoan life is dependent upon the utilization of O(2) for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.

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