Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells - PubMed (original) (raw)
. 2010 Oct 28;46(40):7510-2.
doi: 10.1039/c0cc01560a. Epub 2010 Sep 14.
Affiliations
- PMID: 20838673
- DOI: 10.1039/c0cc01560a
Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells
Alexander R Lippert et al. Chem Commun (Camb). 2010.
Abstract
Lanthanide-based luminescent probes TPR1 and TPR2 were developed for the detection of hydrogen peroxide (H(2)O(2)) in living systems. The chemoselective reaction of these boronate-protected probes with H(2)O(2) resulted in an enhanced lanthanide sensitization and a 6-fold increase in luminescent intensity. TPR2 was utilized to measure the endogenous production of H(2)O(2) in RAW 264.7 macrophages using time-gated luminescent spectroscopy.
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