Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer - PubMed (original) (raw)

Review

. 2010 Nov;16(11):1963-8.

doi: 10.1002/ibd.21281.

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Review

Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer

Linda A Feagins. Inflamm Bowel Dis. 2010 Nov.

Abstract

Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut.

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