Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks - PubMed (original) (raw)

. 2011 Feb 15;18(4):298-302.

doi: 10.1016/j.phymed.2010.08.008. Epub 2010 Sep 18.

Affiliations

• PMID: 20851586
• DOI: 10.1016/j.phymed.2010.08.008

Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks

Zhaolian Lu et al. Phytomedicine. 2011.

Abstract

Procyanidin oligomers in Cinnamon are thought to be responsible for the biological activity in the treatment of diabetes mellitus (DM). To clarify types of procyanidin oligomers in different Cinnamon species and investigate their different effects, the present study investigated procyanidin oligomers in polyphenolic oligomer-rich extracts of three Cinnamon samples by LC-MS methods, and their hypoglycemic activities were detected in vivo and in vitro. The results showed that two of the three samples from Cinnamomum cassia were rich in B-type procyanidin oligomers, and the other sample was rich in A-type procyanidin oligomers. The Cinnamon extracts were administered at doses of 200 and 300 mg/kg body wt. in high-fat diet-fed and low-dose streptozotocin (STZ)-induced diabetic mice for 14 days. The results showed that blood glucose concentrations were significantly decreased in all Cinnamon extract groups compared with the control group (p<0.05). Administration of the Cinnamon extracts significantly increased the consumption of extracellular glucose in insulin-resistant HepG2 cells and normal HepG2 cells compared with the control group. These results suggest that both A- and B-type procyanidin oligomers in different Cinnamon species have hypoglycemic activities and may improve insulin sensitivity in type 2 DM.

Copyright © 2010 Elsevier GmbH. All rights reserved.

PubMed Disclaimer

Similar articles

• Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats.
  Jia Q, Liu X, Wu X, Wang R, Hu X, Li Y, Huang C. Jia Q, et al. Phytomedicine. 2009 Aug;16(8):744-50. doi: 10.1016/j.phymed.2008.12.012. Epub 2009 May 22. Phytomedicine. 2009. PMID: 19464860
• Diverse mechanisms of antidiabetic effects of the different procyanidin oligomer types of two different cinnamon species on db/db mice.
  Chen L, Sun P, Wang T, Chen K, Jia Q, Wang H, Li Y. Chen L, et al. J Agric Food Chem. 2012 Sep 12;60(36):9144-50. doi: 10.1021/jf3024535. Epub 2012 Aug 30. J Agric Food Chem. 2012. PMID: 22920511
• Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats.
  Daisy P, Balasubramanian K, Rajalakshmi M, Eliza J, Selvaraj J. Daisy P, et al. Phytomedicine. 2010 Jan;17(1):28-36. doi: 10.1016/j.phymed.2009.10.018. Phytomedicine. 2010. PMID: 19931438
• Cinnamon intake lowers fasting blood glucose: meta-analysis.
  Davis PA, Yokoyama W. Davis PA, et al. J Med Food. 2011 Sep;14(9):884-9. doi: 10.1089/jmf.2010.0180. Epub 2011 Apr 11. J Med Food. 2011. PMID: 21480806 Review.
• Procyanidins and their healthy protective effects against type 2 diabetes.
  Gonzalez-Abuin N, Pinent M, Casanova-Marti A, Arola L, Blay M, Ardevol A. Gonzalez-Abuin N, et al. Curr Med Chem. 2015;22(1):39-50. doi: 10.2174/0929867321666140916115519. Curr Med Chem. 2015. PMID: 25245512 Review.

Cited by

• Discovery of Cinnamic Acid Derivatives as Potent Anti-H. pylori Agents.
  Li Y, Zhao K, Wu Z, Zheng Y, Yu J, Wu S, Wong VKW, Chen M, Liu W, Zhao S. Li Y, et al. Molecules. 2024 Sep 25;29(19):4548. doi: 10.3390/molecules29194548. Molecules. 2024. PMID: 39407478 Free PMC article.
• Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman.
  Siripongvutikorn S, Pumethakul K, Yupanqui CT, Seechamnanturakit V, Detarun P, Utaipan T, Sirinupong N, Chansuwan W, Wittaya T, Samakradhamrongthai RS. Siripongvutikorn S, et al. Foods. 2024 Feb 14;13(4):582. doi: 10.3390/foods13040582. Foods. 2024. PMID: 38397559 Free PMC article.
• Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections.
  Pacyga K, Pacyga P, Topola E, Viscardi S, Duda-Madej A. Pacyga K, et al. Int J Mol Sci. 2024 Feb 8;25(4):2100. doi: 10.3390/ijms25042100. Int J Mol Sci. 2024. PMID: 38396777 Free PMC article. Review.
• Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms.
  Liu Y, Liu F, Xing D, Wang W, Yang Q, Liao S, Li E, Pang D, Zou Y. Liu Y, et al. Foods. 2023 Oct 20;12(20):3852. doi: 10.3390/foods12203852. Foods. 2023. PMID: 37893745 Free PMC article.
• Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.
  Li W, Lou X, Zha Y, Qin Y, Zha J, Hong L, Xie Z, Yang S, Wang C, An J, Zhang Z, Qiao S. Li W, et al. Elife. 2023 Apr 3;12:e80479. doi: 10.7554/eLife.80479. Elife. 2023. PMID: 37010266 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information