The autoimmune regulator AIRE in thymoma biology: autoimmunity and beyond - PubMed (original) (raw)
Review
. 2010 Oct;5(10 Suppl 4):S266-72.
doi: 10.1097/JTO.0b013e3181f1f63f.
Peter Hohenberger, Hans Hoffmann, Joachim Pfannschmidt, Philipp Schnabel, Hans-Stefan Hofmann, Karsten Wiebe, Berthold Schalke, Wilfred Nix, Ralf Gold, Nick Willcox, Pärt Peterson, Philipp Ströbel
Affiliations
- PMID: 20859117
- DOI: 10.1097/JTO.0b013e3181f1f63f
Free article
Review
The autoimmune regulator AIRE in thymoma biology: autoimmunity and beyond
Alexander Marx et al. J Thorac Oncol. 2010 Oct.
Free article
Abstract
Thymomas are tumors of thymic epithelial cells. They associate more often than any other human tumors with various autoimmune diseases; myasthenia gravis is the commonest, occurring in 10-50% of thymoma patients, depending on the World Health Organization-defined histologic subtype. Most thymomas generate many polyclonal maturing T lymphocytes but in disorganized microenvironments Failure to induce self-tolerance may be a key factor leading to the export of potentially autoreactive CD4 progeny, thus predisposing to autoimmune diseases. Normally, the master Autoimmune Regulator promotes expression of peripheral tissue-restricted antigens such as insulin by medullary thymic epithelial cells and induction of tolerance to them. The failure of approximately 95% of thymomas to express autoimmune regulator is another feature potentially contributing to autoimmunity.
Similar articles
- Autoimmune regulator expression in thymomas with or without autoimmune disease.
Liu Y, Zhang H, Zhang P, Meng F, Chen Y, Wang Y, Yao Y, Qi B. Liu Y, et al. Immunol Lett. 2014 Sep;161(1):50-6. doi: 10.1016/j.imlet.2014.04.008. Epub 2014 Apr 21. Immunol Lett. 2014. PMID: 24768600 - Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity?
Offerhaus GJ, Schipper ME, Lazenby AJ, Montgomery E, Morsink FH, Bende RJ, Musler AR, van Lier RA, van Noesel CJ. Offerhaus GJ, et al. Immunol Lett. 2007 Nov 30;114(1):31-7. doi: 10.1016/j.imlet.2007.08.010. Epub 2007 Sep 29. Immunol Lett. 2007. PMID: 17928069 - Alterations of the immune system in thymic malignancies.
Weksler B, Lu B. Weksler B, et al. J Thorac Oncol. 2014 Sep;9(9 Suppl 2):S137-42. doi: 10.1097/JTO.0000000000000299. J Thorac Oncol. 2014. PMID: 25396311 Review. - Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas.
Scarpino S, Di Napoli A, Stoppacciaro A, Antonelli M, Pilozzi E, Chiarle R, Palestro G, Marino M, Facciolo F, Rendina EA, Webster KE, Kinkel SA, Scott HS, Ruco L. Scarpino S, et al. Clin Exp Immunol. 2007 Sep;149(3):504-12. doi: 10.1111/j.1365-2249.2007.03442.x. Epub 2007 Jun 22. Clin Exp Immunol. 2007. PMID: 17590173 Free PMC article. - Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications.
Kisand K, Lilic D, Casanova JL, Peterson P, Meager A, Willcox N. Kisand K, et al. Eur J Immunol. 2011 Jun;41(6):1517-27. doi: 10.1002/eji.201041253. Epub 2011 May 13. Eur J Immunol. 2011. PMID: 21574164 Review.
Cited by
- Immunotherapy for Thymomas and Thymic Carcinomas: Current Status and Future Directions.
Rajan A, Sivapiromrat AK, McAdams MJ. Rajan A, et al. Cancers (Basel). 2024 Mar 30;16(7):1369. doi: 10.3390/cancers16071369. Cancers (Basel). 2024. PMID: 38611047 Free PMC article. Review. - Myasthenia gravis and five autoimmune diseases: a bidirectional Mendelian randomization study.
Li K, Ouyang Y, Yang H. Li K, et al. Neurol Sci. 2024 Apr;45(4):1699-1706. doi: 10.1007/s10072-023-07163-3. Epub 2023 Nov 1. Neurol Sci. 2024. PMID: 37910321 - Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures.
Zhang X, Zhang P, Cong A, Feng Y, Chi H, Xia Z, Tang H. Zhang X, et al. Front Immunol. 2023 Oct 2;14:1264325. doi: 10.3389/fimmu.2023.1264325. eCollection 2023. Front Immunol. 2023. PMID: 37849766 Free PMC article. Review. - Revisiting Aire and tissue-restricted antigens at single-cell resolution.
Matsumoto M, Yoshida H, Tsuneyama K, Oya T, Matsumoto M. Matsumoto M, et al. Front Immunol. 2023 May 3;14:1176450. doi: 10.3389/fimmu.2023.1176450. eCollection 2023. Front Immunol. 2023. PMID: 37207224 Free PMC article. Review. - AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma.
Matsumoto M, Ohmura T, Hanibuchi Y, Ichimura-Shimizu M, Saijo Y, Ogawa H, Miyazawa R, Morimoto J, Tsuneyama K, Matsumoto M, Oya T. Matsumoto M, et al. Cancer Med. 2023 Apr;12(8):9843-9848. doi: 10.1002/cam4.5777. Epub 2023 Mar 13. Cancer Med. 2023. PMID: 36912123 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials