Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain - PubMed (original) (raw)
. 2010 Dec 17;486(3):246-51.
doi: 10.1016/j.neulet.2010.09.063. Epub 2010 Sep 29.
Affiliations
- PMID: 20887772
- DOI: 10.1016/j.neulet.2010.09.063
Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain
Julie E Simpson et al. Neurosci Lett. 2010.
Abstract
White matter lesions (WML) are associated with dementia and are common in brain ageing. In order to determine whether alteration of the blood-brain barrier (BBB) may contribute to the pathogenesis of WML we assessed albumin leakage and expression of the tight junction (TJ) proteins claudin-5 (Cln-5), zona occludin-1 (ZO-1) and occludin in cases derived from the Medical Research Council Cognitive Function and Ageing Study. Albumin extravasation was widespread in the ageing brain and enhanced in WML, suggesting dysfunction of the BBB may contribute to the pathogenesis of WML. This was not accompanied by significant changes in the endothelial expression of TJ proteins. However, ZO-1 and occludin were expressed by glial cells throughout the parenchyma of both control white matter and WML, suggesting these TJ proteins may have other functions in the brain.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Similar articles
- Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort.
Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG. Viggars AP, et al. Neurosci Lett. 2011 Nov 7;505(1):25-30. doi: 10.1016/j.neulet.2011.09.049. Epub 2011 Sep 28. Neurosci Lett. 2011. PMID: 21970975 - Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise.
Haorah J, Heilman D, Knipe B, Chrastil J, Leibhart J, Ghorpade A, Miller DW, Persidsky Y. Haorah J, et al. Alcohol Clin Exp Res. 2005 Jun;29(6):999-1009. doi: 10.1097/01.alc.0000166944.79914.0a. Alcohol Clin Exp Res. 2005. PMID: 15976526 - Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult.
Jiao H, Wang Z, Liu Y, Wang P, Xue Y. Jiao H, et al. J Mol Neurosci. 2011 Jun;44(2):130-9. doi: 10.1007/s12031-011-9496-4. Epub 2011 Feb 12. J Mol Neurosci. 2011. PMID: 21318404 - Progression of cerebral white matter lesions -- clinical and radiological considerations.
Enzinger C, Fazekas F, Ropele S, Schmidt R. Enzinger C, et al. J Neurol Sci. 2007 Jun 15;257(1-2):5-10. doi: 10.1016/j.jns.2007.01.018. Epub 2007 Feb 23. J Neurol Sci. 2007. PMID: 17321549 Review. - Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach.
Gold G, Kovari E, Hof PR, Bouras C, Giannakopoulos P. Gold G, et al. J Neurol Sci. 2007 Jun 15;257(1-2):17-22. doi: 10.1016/j.jns.2007.01.020. Epub 2007 Feb 23. J Neurol Sci. 2007. PMID: 17321551 Review.
Cited by
- Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke.
Hervella P, Sampedro-Viana A, Fernández-Rodicio S, Rodríguez-Yáñez M, López-Dequidt I, Pumar JM, Mosqueira AJ, Bazarra-Barreiros M, Abengoza-Bello MT, Ortega-Espina S, Ouro A, Pérez-Mato M, Campos F, Sobrino T, Castillo J, Alonso-Alonso ML, Iglesias-Rey R. Hervella P, et al. Int J Mol Sci. 2024 Jun 14;25(12):6554. doi: 10.3390/ijms25126554. Int J Mol Sci. 2024. PMID: 38928260 Free PMC article. - Hsp90 inhibition protects brain endothelial cells against LPS-induced injury.
Uddin MA, Akhter MS, Kubra KT, Barabutis N. Uddin MA, et al. Biofactors. 2022 Jul;48(4):926-933. doi: 10.1002/biof.1833. Epub 2022 Mar 10. Biofactors. 2022. PMID: 35266593 Free PMC article. - The study on analysis of risk factors for severity of white matter lesions and its correlation with cerebral microbleeds in the elderly with lacunar infarction.
Zhou YN, Gao HY, Zhao FF, Liang YC, Gao Y, Liu XH, Wang T, Wang ZG, Wu QJ. Zhou YN, et al. Medicine (Baltimore). 2020 Jan;99(4):e18865. doi: 10.1097/MD.0000000000018865. Medicine (Baltimore). 2020. PMID: 31977887 Free PMC article. - Age-associated white matter lesions: the MRC Cognitive Function and Ageing Study.
Wharton SB, Simpson JE, Brayne C, Ince PG. Wharton SB, et al. Brain Pathol. 2015 Jan;25(1):35-43. doi: 10.1111/bpa.12219. Brain Pathol. 2015. PMID: 25521175 Free PMC article. - Vascular dementia: Current concepts and nomenclature harmonization.
Grinberg LT. Grinberg LT. Dement Neuropsychol. 2012 Jul-Sep;6(3):122-126. doi: 10.1590/S1980-57642012DN06030002. Dement Neuropsychol. 2012. PMID: 29213784 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
- G0300126/MRC_/Medical Research Council/United Kingdom
- G9901400/MRC_/Medical Research Council/United Kingdom
- MC_U105292687/MRC_/Medical Research Council/United Kingdom
- DH_/Department of Health/United Kingdom
LinkOut - more resources
Full Text Sources
Medical