Lineage relationship analysis of RORgammat+ innate lymphoid cells - PubMed (original) (raw)
. 2010 Oct 29;330(6004):665-9.
doi: 10.1126/science.1194597. Epub 2010 Sep 23.
Affiliations
- PMID: 20929731
- DOI: 10.1126/science.1194597
Lineage relationship analysis of RORgammat+ innate lymphoid cells
Shinichiro Sawa et al. Science. 2010.
Abstract
Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt(+) precursors. The fate of RORγt(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts.
Comment in
- Immunology. Innate lymphoid cell relations.
Veldhoen M, Withers DR. Veldhoen M, et al. Science. 2010 Oct 29;330(6004):594-5. doi: 10.1126/science.1198298. Science. 2010. PMID: 21030634 No abstract available.
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