The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes - PubMed (original) (raw)

. 2010 Nov;11(11):1057-62.

doi: 10.1038/ni.1945. Epub 2010 Oct 10.

Claudia Haftmann, Evridiki Sgouroudis, Anja Andrea Kühl, Ahmed Nabil Hegazy, Isabel Panse, Rene Riedel, Michael Flossdorf, Jun Dong, Franziska Fuhrmann, Gitta Anne Heinz, Zhuo Fang, Na Li, Ute Bissels, Farahnaz Hatam, Angelina Jahn, Ben Hammoud, Mareen Matz, Felix-Michael Schulze, Ria Baumgrass, Andreas Bosio, Hans-Joachim Mollenkopf, Joachim Grün, Andreas Thiel, Wei Chen, Thomas Höfer, Christoph Loddenkemper, Max Löhning, Hyun-Dong Chang, Nikolaus Rajewsky, Andreas Radbruch, Mir-Farzin Mashreghi

Affiliations

• PMID: 20935646
• DOI: 10.1038/ni.1945

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

Anna-Barbara Stittrich et al. Nat Immunol. 2010 Nov.

Abstract

After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.

PubMed Disclaimer

Comment in

• Outfoxing Foxo1 with miR-182.
  O'Neill LA. O'Neill LA. Nat Immunol. 2010 Nov;11(11):983-4. doi: 10.1038/ni1110-983. Nat Immunol. 2010. PMID: 20959801 No abstract available.

Similar articles

• B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.
  Lichtman AH, Kurt-Jones EA, Abbas AK. Lichtman AH, et al. Proc Natl Acad Sci U S A. 1987 Feb;84(3):824-7. doi: 10.1073/pnas.84.3.824. Proc Natl Acad Sci U S A. 1987. PMID: 2949327 Free PMC article.
• MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.
  Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. Steiner DF, et al. Immunity. 2011 Aug 26;35(2):169-81. doi: 10.1016/j.immuni.2011.07.009. Epub 2011 Aug 4. Immunity. 2011. PMID: 21820330 Free PMC article.
• Regulation of T lymphocyte activation by microRNA-21.
  Wang L, He L, Zhang R, Liu X, Ren Y, Liu Z, Zhang X, Cheng W, Hua ZC. Wang L, et al. Mol Immunol. 2014 Jun;59(2):163-71. doi: 10.1016/j.molimm.2014.02.004. Epub 2014 Mar 13. Mol Immunol. 2014. PMID: 24631982
• T helper cell differentiation in immune response.
  Reiner SL, Seder RA. Reiner SL, et al. Curr Opin Immunol. 1995 Jun;7(3):360-6. doi: 10.1016/0952-7915(95)80111-1. Curr Opin Immunol. 1995. PMID: 7546401 Review.
• Posttranscriptional Gene Regulation of T Follicular Helper Cells by RNA-Binding Proteins and microRNAs.
  Baumjohann D, Heissmeyer V. Baumjohann D, et al. Front Immunol. 2018 Jul 31;9:1794. doi: 10.3389/fimmu.2018.01794. eCollection 2018. Front Immunol. 2018. PMID: 30108596 Free PMC article. Review.

Cited by

• The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes.
  Gupta N, Somayajulu M, Gurdziel K, LoGrasso G, Aziz H, Rosati R, McClellan S, Pitchaikannu A, Santra M, Shukkur MFA, Stemmer P, Hazlett LD, Xu S. Gupta N, et al. Sci Rep. 2024 Apr 1;14(1):7676. doi: 10.1038/s41598-024-58403-1. Sci Rep. 2024. PMID: 38561433 Free PMC article.
• The role of miRNAs in T helper cell development, activation, fate decisions and tumor immunity.
  Xu SJ, Chen JH, Chang S, Li HL. Xu SJ, et al. Front Immunol. 2024 Jan 9;14:1320305. doi: 10.3389/fimmu.2023.1320305. eCollection 2023. Front Immunol. 2024. PMID: 38264670 Free PMC article. Review.
• A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
  Brunner TM, Serve S, Marx AF, Fadejeva J, Saikali P, Dzamukova M, Durán-Hernández N, Kommer C, Heinrich F, Durek P, Heinz GA, Höfer T, Mashreghi MF, Kühn R, Pinschewer DD, Löhning M. Brunner TM, et al. Nat Immunol. 2024 Feb;25(2):256-267. doi: 10.1038/s41590-023-01697-6. Epub 2024 Jan 3. Nat Immunol. 2024. PMID: 38172258 Free PMC article.
• Role of miR-182 in cardiovascular and cerebrovascular diseases.
  Pei G, Chen L, Wang Y, He C, Fu C, Wei Q. Pei G, et al. Front Cell Dev Biol. 2023 May 9;11:1181515. doi: 10.3389/fcell.2023.1181515. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37228653 Free PMC article. Review.
• MicroRNA-183/96/182 cluster in immunity and autoimmunity.
  Wang Z, Dai R, Ahmed SA. Wang Z, et al. Front Immunol. 2023 Feb 20;14:1134634. doi: 10.3389/fimmu.2023.1134634. eCollection 2023. Front Immunol. 2023. PMID: 36891312 Free PMC article. Review.

References

1. 1. Immunity. 2009 Mar 20;30(3):358-71 - PubMed
2. 1. J Immunol. 1997 Jun 15;158(12):5717-26 - PubMed
3. 1. J Immunol. 2008 Jun 15;180(12):7919-30 - PubMed
4. 1. Eur J Immunol. 2008 Oct;38(10):2654-64 - PubMed
5. 1. J Immunol. 2005 Apr 1;174(7):4161-71 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • H1 Connect

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal