The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes - PubMed (original) (raw)

. 2010 Nov;11(11):1057-62.

doi: 10.1038/ni.1945. Epub 2010 Oct 10.

Claudia Haftmann, Evridiki Sgouroudis, Anja Andrea Kühl, Ahmed Nabil Hegazy, Isabel Panse, Rene Riedel, Michael Flossdorf, Jun Dong, Franziska Fuhrmann, Gitta Anne Heinz, Zhuo Fang, Na Li, Ute Bissels, Farahnaz Hatam, Angelina Jahn, Ben Hammoud, Mareen Matz, Felix-Michael Schulze, Ria Baumgrass, Andreas Bosio, Hans-Joachim Mollenkopf, Joachim Grün, Andreas Thiel, Wei Chen, Thomas Höfer, Christoph Loddenkemper, Max Löhning, Hyun-Dong Chang, Nikolaus Rajewsky, Andreas Radbruch, Mir-Farzin Mashreghi

Affiliations

• PMID: 20935646
• DOI: 10.1038/ni.1945

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

Anna-Barbara Stittrich et al. Nat Immunol. 2010 Nov.

Abstract

After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.

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Comment in

• Outfoxing Foxo1 with miR-182.
  O'Neill LA. O'Neill LA. Nat Immunol. 2010 Nov;11(11):983-4. doi: 10.1038/ni1110-983. Nat Immunol. 2010. PMID: 20959801 No abstract available.

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