Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion - PubMed (original) (raw)
Comparative Study
doi: 10.1002/jnr.22524.
Kentaro Deguchi, Yasuyuki Ohta, Ning Liu, Xuemei Zhang, Fengfeng Tian, Toru Yamashita, Yoshio Ikeda, Tohru Matsuura, Hiroshi Funakoshi, Toshikazu Nakamura, Koji Abe
Affiliations
- PMID: 20963849
- DOI: 10.1002/jnr.22524
Comparative Study
Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion
Jingwei Shang et al. J Neurosci Res. 2011 Jan.
Abstract
Hepatocyte growth factor (HGF) and glial cell line-derived neurotrophic factor (GDNF) are strong neurotrophic factors. However, their potentials in neurogenesis, angiogenesis, synaptogenesis, and antifibrosis have not been compared. Therefore, we investigated these effects of HGF and GDNF in cerebral ischemia in the rat. Wistar rats were subjected to 90 min of transient middle cerebral artery occlusion (tMCAO). Immediately after reperfusion, HGF or GDNF was given by topical application. BrdU was injected intraperitoneally twice daily 1, 2, and 3 days after tMCAO. On 14 day, we histologically evaluated infarct volume, antiapoptotic effect, neurogenesis, angiogenesis, synaptogenesis, and antifibrosis. Both HGF and GDNF significantly reduced infarct size and the number of TUNEL-positive cells, but only HGF significantly increased the number of BrdU-positive cells in the subventricular zone, and 5'-bromo-2'-deoxyuridine -positive cells differentiated into mature neurons on the ischemic side. Enhancement of angiogenesis and synaptogenesis at the ischemic boundary zone was also observed only in HGF-treated rats. HGF significantly decreased the glial scar formation and scar thickness of the brain pia mater after tMCAO, but GDNF did not. Our study shows that both HGF and GDNF had significant neurotrophic effects, but only HGF can promote the neurogenesis, angiogenesis, and synaptogenesis and inhibit fibrotic change in brains after tMCAO.
© 2010 Wiley-Liss, Inc.
Similar articles
- Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats.
Shang J, Deguchi K, Yamashita T, Ohta Y, Zhang H, Morimoto N, Liu N, Zhang X, Tian F, Matsuura T, Funakoshi H, Nakamura T, Abe K. Shang J, et al. J Neurosci Res. 2010 Aug 1;88(10):2197-206. doi: 10.1002/jnr.22373. J Neurosci Res. 2010. PMID: 20175208 - Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats.
Bao X, Feng M, Wei J, Han Q, Zhao H, Li G, Zhu Z, Xing H, An Y, Qin C, Zhao RC, Wang R. Bao X, et al. Eur J Neurosci. 2011 Jul;34(1):87-98. doi: 10.1111/j.1460-9568.2011.07733.x. Epub 2011 Jun 21. Eur J Neurosci. 2011. PMID: 21692879 - Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats.
Chen B, Gao XQ, Yang CX, Tan SK, Sun ZL, Yan NH, Pang YG, Yuan M, Chen GJ, Xu GT, Zhang K, Yuan QL. Chen B, et al. Brain Res. 2009 Aug 11;1284:1-11. doi: 10.1016/j.brainres.2009.05.100. Epub 2009 Jun 9. Brain Res. 2009. PMID: 19520066 - Recent Progress in Therapeutic Strategies for Ischemic Stroke.
Yamashita T, Abe K. Yamashita T, et al. Cell Transplant. 2016;25(5):893-8. doi: 10.3727/096368916X690548. Epub 2016 Jan 18. Cell Transplant. 2016. PMID: 26786838 Review. - [Ischemic brain injury and hepatocyte growth factor].
Takeo S, Takagi N, Takagi K. Takeo S, et al. Yakugaku Zasshi. 2007 Nov;127(11):1813-23. doi: 10.1248/yakushi.127.1813. Yakugaku Zasshi. 2007. PMID: 17978557 Review. Japanese.
Cited by
- Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain.
Nakaguchi K, Jinnou H, Kaneko N, Sawada M, Hikita T, Saitoh S, Tabata Y, Sawamoto K. Nakaguchi K, et al. Stem Cells Int. 2012;2012:915160. doi: 10.1155/2012/915160. Epub 2012 Oct 10. Stem Cells Int. 2012. PMID: 23093979 Free PMC article. - Extracellular vesicle-mediated bidirectional communication between heart and other organs.
Gabisonia K, Khan M, Recchia FA. Gabisonia K, et al. Am J Physiol Heart Circ Physiol. 2022 May 1;322(5):H769-H784. doi: 10.1152/ajpheart.00659.2021. Epub 2022 Feb 18. Am J Physiol Heart Circ Physiol. 2022. PMID: 35179973 Free PMC article. Review. - Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients.
Cichoń N, Bijak M, Czarny P, Miller E, Synowiec E, Sliwinski T, Saluk-Bijak J. Cichoń N, et al. Front Aging Neurosci. 2018 Sep 26;10:294. doi: 10.3389/fnagi.2018.00294. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30319398 Free PMC article. - Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models.
Lee SH, Kim S, Lee N, Lee J, Yu SS, Kim JH, Kim S. Lee SH, et al. Acta Neuropathol Commun. 2019 Jun 12;7(1):96. doi: 10.1186/s40478-019-0737-z. Acta Neuropathol Commun. 2019. PMID: 31189468 Free PMC article. - Importance of the brain Angiotensin system in Parkinson's disease.
Wright JW, Harding JW. Wright JW, et al. Parkinsons Dis. 2012;2012:860923. doi: 10.1155/2012/860923. Epub 2012 Nov 7. Parkinsons Dis. 2012. PMID: 23213621 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources