Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease - PubMed (original) (raw)
Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease
Hyun-Sub Um et al. Neurosci Res. 2011 Feb.
Abstract
The present study was undertaken to further investigate the protective effect of treadmill exercise on the hippocampal proteins associated with neuronal cell death in an aged transgenic (Tg) mice with Alzheimer's disease (AD). To address this, Tg mouse model of AD, Tg-NSE/PS2m, which expresses human mutant PS2 in the brain, was chosen. Animals were subjected to treadmill exercise for 12 weeks from 24 months of age. The exercised mice were treadmill run at speed of 12 m/min, 60 min/day, 5 days/week on a 0% gradient for 3 months. Treadmill exercised mice improved cognitive function in water maze test. Treadmill exercised mice significantly reduced the expression of Aβ-42, Cox-2, and caspase-3 in the hippocampus. In parallel, treadmill exercised Tg mice decreased the phosphorylation levels of JNK, p38MAPK and tau (Ser404, Ser202, Thr231), and increased the phosphorylation levels of ERK, PI3K, Akt and GSK-3α/β. In addition, treadmill exercised Tg mice up-regulated the expressions of NGF, BDNF and phospho-CREB, and the expressions of SOD-1, SOD-2 and HSP-70. Treadmill exercised Tg mice up-regulated the expression of Bcl-2, and down-regulated the expressions of cytochrome c and Bax in the hippocampus. The number of TUNEL-positive cells in the hippocampus in mice was significantly decreased after treadmill exercise. Finally, serum TC, insulin, glucose, and corticosterone levels were significantly decreased in the Tg mice after treadmill exercise. As a consequence of such change, Aβ-dependent neuronal cell death in the hippocampus of Tg mice was markedly suppressed following treadmill exercise. These results strongly suggest that treadmill exercise provides a therapeutic potential to inhibit both Aβ-42 and neuronal death pathways. Therefore, treadmill exercise may be beneficial in prevention or treatment of AD.
Copyright © 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Similar articles
- Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.
Leem YH, Lim HJ, Shim SB, Cho JY, Kim BS, Han PL. Leem YH, et al. J Neurosci Res. 2009 Aug 15;87(11):2561-70. doi: 10.1002/jnr.22075. J Neurosci Res. 2009. PMID: 19360903 - Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice.
Kang EB, Kwon IS, Koo JH, Kim EJ, Kim CH, Lee J, Yang CH, Lee YI, Cho IH, Cho JY. Kang EB, et al. Apoptosis. 2013 Nov;18(11):1332-1347. doi: 10.1007/s10495-013-0884-9. Apoptosis. 2013. PMID: 23907580 - Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice.
Liu HL, Zhao G, Zhang H, Shi LD. Liu HL, et al. Behav Brain Res. 2013 Nov 1;256:261-72. doi: 10.1016/j.bbr.2013.08.008. Epub 2013 Aug 19. Behav Brain Res. 2013. PMID: 23968591 - Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.
Dinda B, Dinda M, Kulsi G, Chakraborty A, Dinda S. Dinda B, et al. Eur J Med Chem. 2019 May 1;169:185-199. doi: 10.1016/j.ejmech.2019.03.009. Epub 2019 Mar 8. Eur J Med Chem. 2019. PMID: 30877973 Review. - Beneficial effects of moderate voluntary physical exercise and its biological mechanisms on brain health.
Ma Q. Ma Q. Neurosci Bull. 2008 Aug;24(4):265-70. doi: 10.1007/s12264-008-0402-1. Neurosci Bull. 2008. PMID: 18668156 Free PMC article. Review.
Cited by
- Death by a thousand cuts in Alzheimer's disease: hypoxia--the prodrome.
Daulatzai MA. Daulatzai MA. Neurotox Res. 2013 Aug;24(2):216-43. doi: 10.1007/s12640-013-9379-2. Epub 2013 Feb 12. Neurotox Res. 2013. PMID: 23400634 Review. - Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models.
Corsetti V, Borreca A, Latina V, Giacovazzo G, Pignataro A, Krashia P, Natale F, Cocco S, Rinaudo M, Malerba F, Florio R, Ciarapica R, Coccurello R, D'Amelio M, Ammassari-Teule M, Grassi C, Calissano P, Amadoro G. Corsetti V, et al. Brain Commun. 2020 Apr 6;2(1):fcaa039. doi: 10.1093/braincomms/fcaa039. eCollection 2020. Brain Commun. 2020. PMID: 32954296 Free PMC article. - Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress.
Amraie E, Pouraboli I, Salehi H, Rajaei Z. Amraie E, et al. Metab Brain Dis. 2023 Mar;38(3):999-1011. doi: 10.1007/s11011-022-01140-z. Epub 2022 Dec 8. Metab Brain Dis. 2023. PMID: 36478529 - Epigenetic Modifications of the _α_-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects.
Daniele S, Costa B, Pietrobono D, Giacomelli C, Iofrida C, Trincavelli ML, Fusi J, Franzoni F, Martini C. Daniele S, et al. Oxid Med Cell Longev. 2018 Apr 15;2018:3740345. doi: 10.1155/2018/3740345. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 29849887 Free PMC article. - Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy.
Robison LS, Popescu DL, Anderson ME, Francis N, Hatfield J, Sullivan JK, Beigelman SI, Xu F, Anderson BJ, Van Nostrand WE, Robinson JK. Robison LS, et al. J Neuroinflammation. 2019 Jul 11;16(1):144. doi: 10.1186/s12974-019-1534-0. J Neuroinflammation. 2019. PMID: 31296239 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous