Hedonic and nucleus accumbens neural responses to a natural reward are regulated by aversive conditioning - PubMed (original) (raw)
Hedonic and nucleus accumbens neural responses to a natural reward are regulated by aversive conditioning
Mitchell F Roitman et al. Learn Mem. 2010.
Abstract
The nucleus accumbens (NAc) plays a role in hedonic reactivity to taste stimuli. Learning can alter the hedonic valence of a given stimulus, and it remains unclear how the NAc encodes this shift. The present study examined whether the population response of NAc neurons to a taste stimulus is plastic using a conditioned taste aversion (CTA) paradigm. Electrophysiological and electromyographic (EMG) responses to intraoral infusions of a sucrose (0.3 M) solution were made in naïve rats (Day 1). Immediately following the session, half of the rats (n = 6; Paired) received an injection of lithium chloride (0.15 M; i.p.) to induce malaise and establish a CTA while the other half (n = 6; Unpaired) received a saline injection. Days later (Day 5), NAc recordings during infusions of sucrose were again made. Electrophysiological and EMG responses to sucrose did not differ between groups on Day 1. For both groups, the majority of sucrose responsive neurons exhibited a decrease in firing rate (77% and 71% for Paired and Unpaired, respectively). Following conditioning, in Paired rats, EMG responses were indicative of aversion. Moreover, the majority of responsive NAc neurons now exhibited an increase in firing rate (69%). Responses in Unpaired rats were unchanged by the experience. Thus, the NAc differentially encodes the hedonic value of the same stimulus based on learned associations.
Figures
Figure 1.
EMG responses of the anterior digastric muscle to intraorally infused sucrose reflect the formation of a CTA. (A) Representative raw EMG trace recorded from the anterior digastric muscle in an Unpaired rat. (B) Representative raw EMG trace recorded from the anterior digastric muscle in a Paired rat. In both A and B, vertical red lines denote, from left to right, the beginning and end of the 4-sec intraoral infusion of 0.3 M sucrose. In Unpaired rats (n = 6), experience with sucrose (Day 5, red) and LiCl injections did not alter the number (C) or duration (E) of EMG responses across the 30-trial intraoral infusion session relative to the EMG responses observed in the same rats on Day 1 (blue). In Paired rats (n = 6), experience with sucrose (Day 5, red) and LiCl injections led to significant decreases in the number (D) and increases in the duration (F) of EMG responses across the 30-trial intraoral infusion session relative to the EMG responses observed in the same rats on Day 1 (blue).
Figure 2.
Histological verification of electrode placements. Lesion sites in Unpaired (left) and Paired (right) rats of confirmed electrode placements in the nucleus accumbens are shown. Placements in the NAc are based on a stereotaxic atlas (Paxinos and Watson 2007).
Figure 3.
Raster plots (above) and perievent histograms (below) of two representative cells in the NAc that respond to intraoral infusions of sucrose. (A) An increasing neuron recorded in a Paired rat on Day 5. (B) A decreasing neuron recorded in an Unpaired rat on Day 5. For both graphs, data are aligned to the onset of the infusion (t = 0 sec) and the horizontal black bar denotes the duration of the intraoral infusion.
Figure 4.
In Unpaired rats, experience does not affect the population response of NAc neurons to intraoral infusions of sucrose. (Left) Representation of all sucrose responsive NAc neurons recorded on Day 1, under naïve conditions. (A) The colorplot shows the normalized firing rate (1-sec bins) of each neuron that had a statistically significant change in firing rate in response to intraoral infusions. Each row represents the activity of one neuron. Data are aligned to the start of the intraoral infusion (t = 0 sec). Normalized firing rate is shown in color. Neurons are organized such that the strongest increasing neuron is at the top and the strongest decreasing neuron is on the bottom. Increasing neurons are highlighted by the red letter “I” and number. The horizontal dashed white line separates neurons that exhibited a significant increase (above; n = 15) from those that exhibited a significant decrease (n = 36) in firing rate in response to sucrose infusions. Decreasing neurons are highlighted by the blue letter “D” and number. (C) Average normalized response of decreasing (blue circles) and increasing (red circles) neurons as well as the overall population response (green circles) to sucrose infusions on Day 1. (Right) Representation of all sucrose responsive NAc neurons recorded on Day 5, after explicitly Unpaired LiCl experience. (B) Increasing (n = 12) and decreasing (n = 24) neurons recorded on Day 5 are shown as in A. (D) Average normalized response of decreasing (blue circles) and increasing (red circles) neurons as well as the overall population response (green circles) to sucrose infusions on Day 5. The ratio of increasing to decreasing neurons was no different on Day 1 vs. Day 5 (χ2 = 0.00; P > 0.05).
Figure 5.
In Paired rats, experience alters the population response of NAc neurons to intraoral infusions of sucrose. Left: Representation of all sucrose responsive NAc neurons recorded on Day 1, under naïve conditions. (A) The colorplot shows the normalized firing rate (1-sec bins) of each neuron that had a statistically significant change in firing rate in response to intraoral infusions. Each row represents the activity of one neuron. Data are aligned to the start of the intraoral infusion (t = 0 sec). Normalized firing rate is shown in color. Neurons are organized such that the strongest increasing neuron is at the top and the strongest decreasing neuron is on the bottom. Increasing neurons are highlighted by the red letter “I” and number. The horizontal dashed white line separates neurons that exhibited a significant increase (above; n = 8) from those that exhibited a significant decrease (n = 27) in firing rate in response to sucrose infusions. Decreasing neurons are highlighted by the blue letter “D” and number. (C) Average normalized response of decreasing (blue circles) and increasing (red circles) neurons as well as the overall population response (green circles) to sucrose infusions on Day 1. Right: Representation of all sucrose responsive NAc neurons recorded on Day 5, after explicitly Paired LiCl experience. (B) Increasing (n = 27) and decreasing (n = 12) neurons are shown as in A. (D) Average normalized response of decreasing (blue circles) and increasing (red circles) neurons as well as the overall population response (green circles) to sucrose infusions on Day 5. Importantly, the ratio of increasing to decreasing neurons was significantly different on Day 5 vs. Day 1 (χ2 = 47.75; P < 0.001).
Figure 6.
Although the magnitude of increased and decreased responses do not differ across days of testing, the overall response across the population reflects a hedonic shift. (A) The magnitude of the response to sucrose of increasing (solid outlined bars) and decreasing (dashed outlined bars) neurons does not differ based on day (Day 1 vs. Day 5) or pairing (Unpaired vs. Paired). (B) The average firing rate for all sucrose-responsive neurons changes based on pairing. The average firing rate was significantly higher on Day 5 but only in Paired rats. Bars represent means ± 1 SEM. (*) Denotes significant difference (P < 0.001) relative to all other bars.
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