Inside the microbial and immune labyrinth: Gut microbes: friends or fiends? - PubMed (original) (raw)

Inside the microbial and immune labyrinth: Gut microbes: friends or fiends?

Warren Strober. Nat Med. 2010 Nov.

No abstract available

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The author declares no competing financial interests.

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Figure 1

Figure 1

Regulation of colitis by PSA through the induction of Treg cells. PSA produced by the commensal organism B. fragilis in the gut lumen is taken up by intestinal dendritic cells. These immune cells then present PSA to naive CD4+ T cells, which recognize this antigen and undergo Treg cell differentiation under the influence of TGF-β and retinoic acid secreted by the dendritic cell. This may occur in either the lamina propria or the draining mesenteric lymph nodes. During Treg cell induction, PSA is presented to the T cell via a conventional major histocompatibility complex–antigen–T cell interaction; however, PSA could also influence induction through the activation of TLR2 on the surface of either the presenting dendritic cell or the nascent Treg cell. The induced Treg cells then migrate to the inflamed gut, where they downregulate IFN-γ– or IL-17–secreting proinflammatory T cells (which mediate TNBS-induced colitis) by releasing the antiinflammatory cytokines TGF-β, IL-10 or both.

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