Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity - PubMed (original) (raw)

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

K Sugawara et al. J Antibiot (Tokyo). 1990 Jan.

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Abstract

Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

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