C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus - PubMed (original) (raw)
C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus
S K Kim et al. Cell. 1990.
Free article
Abstract
During fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. From nascent wild-type fruiting bodies we have purified a polypeptide of 17 kd called C-factor, which, at approximately 1 to 2 nM, restores normal development to csgA mutant cells. C-factor activity is not recovered from extracts of unstarved, growing cells or csgA mutant cells. The amino acid sequence from purified C-factor demonstrates that it is the product of the csgA gene. C-factor is active over a narrow range of concentration and has properties of a morphogenetic paracrine signal.
Similar articles
- C-factor has distinct aggregation and sporulation thresholds during Myxococcus development.
Kim SK, Kaiser D. Kim SK, et al. J Bacteriol. 1991 Mar;173(5):1722-8. doi: 10.1128/jb.173.5.1722-1728.1991. J Bacteriol. 1991. PMID: 1847908 Free PMC article. - Purification and properties of Myxococcus xanthus C-factor, an intercellular signaling protein.
Kim SK, Kaiser D. Kim SK, et al. Proc Natl Acad Sci U S A. 1990 May;87(10):3635-9. doi: 10.1073/pnas.87.10.3635. Proc Natl Acad Sci U S A. 1990. PMID: 2111012 Free PMC article. - Control of morphogenesis in myxobacteria.
Shimkets LJ. Shimkets LJ. Crit Rev Microbiol. 1987;14(3):195-227. doi: 10.3109/10408418709104439. Crit Rev Microbiol. 1987. PMID: 3107905 Review. - How and why myxobacteria talk to each other.
Kaiser D. Kaiser D. Curr Opin Microbiol. 1998 Dec;1(6):663-8. doi: 10.1016/s1369-5274(98)80112-4. Curr Opin Microbiol. 1998. PMID: 10066550 Review.
Cited by
- devI is an evolutionarily young negative regulator of Myxococcus xanthus development.
Rajagopalan R, Wielgoss S, Lippert G, Velicer GJ, Kroos L. Rajagopalan R, et al. J Bacteriol. 2015 Apr;197(7):1249-62. doi: 10.1128/JB.02542-14. Epub 2015 Feb 2. J Bacteriol. 2015. PMID: 25645563 Free PMC article. - Low-temperature induction of Myxococcus xanthus developmental gene expression in wild-type and csgA suppressor cells.
Rhie HG, Shimkets LJ. Rhie HG, et al. J Bacteriol. 1991 Apr;173(7):2206-11. doi: 10.1128/jb.173.7.2206-2211.1991. J Bacteriol. 1991. PMID: 1901052 Free PMC article. - Molecular cloning, sequence analysis, and characterization of a penicillin-resistant DD-carboxypeptidase of Myxococcus xanthus.
Kimura Y, Takashima Y, Tokumasu Y, Sato M. Kimura Y, et al. J Bacteriol. 1999 Aug;181(15):4696-9. doi: 10.1128/JB.181.15.4696-4699.1999. J Bacteriol. 1999. PMID: 10419975 Free PMC article. - Providencia stuartii genes activated by cell-to-cell signaling and identification of a gene required for production or activity of an extracellular factor.
Rather PN, Ding X, Baca-DeLancey RR, Siddiqui S. Rather PN, et al. J Bacteriol. 1999 Dec;181(23):7185-91. doi: 10.1128/JB.181.23.7185-7191.1999. J Bacteriol. 1999. PMID: 10572119 Free PMC article. - Global mutational analysis of NtrC-like activators in Myxococcus xanthus: identifying activator mutants defective for motility and fruiting body development.
Caberoy NB, Welch RD, Jakobsen JS, Slater SC, Garza AG. Caberoy NB, et al. J Bacteriol. 2003 Oct;185(20):6083-94. doi: 10.1128/JB.185.20.6083-6094.2003. J Bacteriol. 2003. PMID: 14526020 Free PMC article.