Dietary phytoestrogens and the risk of ovarian cancer in the women's lifestyle and health cohort study - PubMed (original) (raw)
Randomized Controlled Trial
Dietary phytoestrogens and the risk of ovarian cancer in the women's lifestyle and health cohort study
Maria Hedelin et al. Cancer Epidemiol Biomarkers Prev. 2011 Feb.
Abstract
Background: Dietary intake of phytoestrogens has been inversely associated to hormone-dependent cancers, such as prostate and breast cancers. Few studies have investigated the association between ovarian cancer and intake of phytoestrogens. We evaluated the associations between intake of phytoestrogens (isoflavonoids/lignans/coumestrol) and fiber (vegetable/cereal) and risk of ovarian cancer.
Methods: In 1991-1992 a prospective population-based cohort study among Swedish women was conducted, including 47,140 women with complete dietary questionnaire data. During follow-up until December 2007, 163 women developed invasive (n = 117) and borderline (n = 46) ovarian cancers. The median follow-up time was 16 years and total person year was 747,178. Cox proportional hazards models were conducted to estimate multivariate risk ratios, 95% CI for associations with risk of ovarian cancer.
Results: We found no association between intake of phytoestrogens or fiber and overall ovarian cancer risk. In addition, we found no statistically significant association between intake of specific food items rich in phytoestrogens (berries, nuts, beans/soy, and crisp or whole-grain bread) and ovarian cancer risk overall. Fiber and coumestrol was inversely associated with borderline ovarian cancer, but not with invasive ovarian cancer.
Conclusions: We found no association between intake of phytoestrogens or fiber and overall ovarian cancer risk.
Impact: Phytoestrogens do not play a major etiologic role in ovarian cancer, at least among women in this Swedish cohort with low bean/soy intake. However, our results of a difference in the effect of fiber or coumestrol between invasive and borderline ovarian cancer need to be evaluated in larger studies.
©2011 AACR.
Similar articles
- Dietary fiber intake and ovarian cancer risk: a prospective cohort study.
Silvera SA, Jain M, Howe GR, Miller AB, Rohan TE. Silvera SA, et al. Cancer Causes Control. 2007 Apr;18(3):335-41. doi: 10.1007/s10552-006-0107-6. Epub 2007 Feb 6. Cancer Causes Control. 2007. PMID: 17285261 - Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer.
Hedelin M, Bälter KA, Chang ET, Bellocco R, Klint A, Johansson JE, Wiklund F, Thellenberg-Karlsson C, Adami HO, Grönberg H. Hedelin M, et al. Prostate. 2006 Oct 1;66(14):1512-20. doi: 10.1002/pros.20487. Prostate. 2006. PMID: 16921512 - Phytoestrogens and prostate cancer risk.
Ganry O. Ganry O. Prev Med. 2005 Jul;41(1):1-6. doi: 10.1016/j.ypmed.2004.10.022. Epub 2004 Dec 9. Prev Med. 2005. PMID: 15916986 Review. - Dietary fiber, phytoestrogens, and breast cancer.
Rose DP. Rose DP. Nutrition. 1992 Jan-Feb;8(1):47-51. Nutrition. 1992. PMID: 1314118 Review.
Cited by
- Diabetes risk reduction diet and ovarian cancer risk: an Italian case-control study.
Esposito G, Turati F, Parazzini F, Augustin LSA, Serraino D, Negri E, La Vecchia C. Esposito G, et al. Cancer Causes Control. 2023 Sep;34(9):769-776. doi: 10.1007/s10552-023-01722-x. Epub 2023 May 24. Cancer Causes Control. 2023. PMID: 37221355 Free PMC article. - Effects on Serum Hormone Concentrations after a Dietary Phytoestrogen Intervention in Patients with Prostate Cancer: A Randomized Controlled Trial.
Ahlin R, Nørskov NP, Nybacka S, Landberg R, Skokic V, Stranne J, Josefsson A, Steineck G, Hedelin M. Ahlin R, et al. Nutrients. 2023 Apr 6;15(7):1792. doi: 10.3390/nu15071792. Nutrients. 2023. PMID: 37049632 Free PMC article. Clinical Trial. - Consumption of flavonoids and risk of hormone-related cancers: a systematic review and meta-analysis of observational studies.
Liu F, Peng Y, Qiao Y, Huang Y, Song F, Zhang M, Song F. Liu F, et al. Nutr J. 2022 May 11;21(1):27. doi: 10.1186/s12937-022-00778-w. Nutr J. 2022. PMID: 35545772 Free PMC article. - Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality.
Fan Y, Wang M, Li Z, Jiang H, Shi J, Shi X, Liu S, Zhao J, Kong L, Zhang W, Ma L. Fan Y, et al. Front Nutr. 2022 Mar 4;9:847421. doi: 10.3389/fnut.2022.847421. eCollection 2022. Front Nutr. 2022. PMID: 35308286 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical