Is Huntington disease a developmental disorder? - PubMed (original) (raw)

Is Huntington disease a developmental disorder?

Sandrine Humbert. EMBO Rep. 2010 Dec.

Abstract

The recently discovered roles of huntingtin in non-differentiated cells indicate that it is a key molecule in brain development. Humbert argues that the haploinsufficiency of wild-type huntingtin in Huntington disease might lead to various cellular alterations well before the onset of symptoms and ultimately cause disease.

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