Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues - PubMed (original) (raw)
Review
. 2010 Dec;52(6):2206-15.
doi: 10.1002/hep.24042.
Affiliations
- PMID: 21105109
- DOI: 10.1002/hep.24042
Review
Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues
Vlad Ratziu et al. Hepatology. 2010 Dec.
Abstract
Insulin sensitizers are attractive candidate therapies for nonalcoholic steatohepatitis mainly because of the strong association between this disease and insulin resistance. This review provides a critical overview of the mechanisms of action, clinical trial results, and safety issues of metformin and glitazones in nonalcoholic steatohepatitis. It also highlights methodological challenges for trial design and proposes endpoints for future proof of principle, registrational, and postmarketing trials.
Copyright © 2010 American Association for the Study of Liver Diseases.
Comment in
- Insulin sensitizers in nonalcoholic steatohepatitis.
Harrison SA, Schenker S, Cusi K. Harrison SA, et al. Hepatology. 2011 Apr;53(4):1404-5; author reply 1405. doi: 10.1002/hep.24179. Hepatology. 2011. PMID: 21480350 No abstract available.
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