Stressed-out mitochondria get MAD - PubMed (original) (raw)

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Stressed-out mitochondria get MAD

Marc Chatenay-Lapointe et al. Cell Metab. 2010.

Abstract

Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degradation of damaged organelles. A recent study in Molecular Cell (Heo et al., 2010) adds another mechanism to this mitochondrial homeostasis toolkit: mitochondria-associated protein degradation (MAD) that ultimately directs endoplasmic reticulum-associated protein degradation (ERAD) pathway components to oxidatively stressed mitochondria.

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• A stress-responsive system for mitochondrial protein degradation.
  Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J. Heo JM, et al. Mol Cell. 2010 Nov 12;40(3):465-80. doi: 10.1016/j.molcel.2010.10.021. Mol Cell. 2010. PMID: 21070972 Free PMC article.

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