ACE2 and diabetes: ACE of ACEs? - PubMed (original) (raw)

Comment

ACE2 and diabetes: ACE of ACEs?

Daniel Batlle et al. Diabetes. 2010 Dec.

No abstract available

Figures

FIG. 1.

Potential therapeutic role of ACE2 amplification in diabetes, both at the level of the pancreatic islets and at that of the kidney. ACE2 amplification leads to reduced Ang II overactivity and increased Ang-(1–7) activity. Please note that the actions of ACE2 on angiotensin peptides are just the opposite of those of ACE, which promotes Ang II formation while increasing Ang-(1–7) degradation. In general, the effects of Ang-(1–7) (blue) are less well documented (as reflected by the question marks) than those of Ang II (red). It is possible that the benefits of ACE2 amplification result largely from reduced ACE2 overactivity and not so much from increased Ang-(1–7) activity, but that needs to be further studied. There are also potential effects of Ang-(1–7) on insulin sensitivity (not shown).

Comment on

Angiotensin I-converting enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic mice.
Bindom SM, Hans CP, Xia H, Boulares AH, Lazartigues E. Bindom SM, et al. Diabetes. 2010 Oct;59(10):2540-8. doi: 10.2337/db09-0782. Epub 2010 Jul 26. Diabetes. 2010. PMID: 20660625 Free PMC article.

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ACE2 and diabetes: ACE of ACEs? - PubMed (original) (raw)