Mitophagy: the latest problem for Parkinson's disease - PubMed (original) (raw)
Review
Mitophagy: the latest problem for Parkinson's disease
Cristofol Vives-Bauza et al. Trends Mol Med. 2011 Mar.
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. Some familial forms of PD are provoked by mutations in the genes encoding for the PTEN (phosphatase and tensin homolog)-induced putative kinase-1 (PINK1) and Parkin. Mounting evidence indicates that PINK1 and Parkin might function in concert to modulate mitochondrial degradation, termed mitophagy. However, the molecular mechanisms by which PINK1/Parkin affect mitophagy are just beginning to be elucidated. Herein, we review the main advances in our understanding of the PINK1/Parkin pathway. Because of the phenotypic similarities among the different forms of PD, a better understanding of PINK1/Parkin biology might have far-reaching pathogenic and therapeutic implications for both the inherited and the sporadic forms of PD.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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