Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection - PubMed (original) (raw)
Comparative Study
. 2011 Jan 15;186(2):745-53.
doi: 10.4049/jimmunol.1002807. Epub 2010 Dec 10.
Affiliations
- PMID: 21148794
- DOI: 10.4049/jimmunol.1002807
Comparative Study
Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection
Pragati Nigam et al. J Immunol. 2011.
Abstract
Progressive disease caused by pathogenic SIV/HIV infections is marked by systemic hyperimmune activation, immune dysregulation, and profound depletion of CD4(+) T cells in lymphoid and gastrointestinal mucosal tissues. IL-17 is important for protective immunity against extracellular bacterial infections at mucosa and for maintenance of mucosal barrier. Although IL-17-secreting CD4 (Th17) and CD8 (Tc17) T cells have been reported, very little is known about the latter subset for any infectious disease. In this study, we characterized the anatomical distribution, phenotype, and functional quality of Tc17 and Th17 cells in healthy (SIV-) and SIV+ rhesus macaques. In healthy macaques, Tc17 and Th17 cells were present in all lymphoid and gastrointestinal tissues studied with predominance in small intestine. About 50% of these cells coexpressed TNF-α and IL-2. Notably, ∼50% of Tc17 cells also expressed the co-inhibitory molecule CTLA-4, and only a minority (<20%) expressed granzyme B suggesting that these cells possess more of a regulatory than cytotoxic phenotype. After SIV infection, unlike Th17 cells, Tc17 cells were not depleted during the acute phase of infection. However, the frequency of Tc17 cells in SIV-infected macaques with AIDS was lower compared with that in healthy macaques demonstrating the loss of these cells during end-stage disease. Antiretroviral therapy partially restored the frequency of Tc17 and Th17 cells in the colorectal mucosa. Depletion of Tc17 cells was not observed in colorectal mucosa of chronically infected SIV+ sooty mangabeys. In conclusion, our results suggest a role for Tc17 cells in regulating disease progression during pathogenic SIV infection.
Similar articles
- Th17 cells in natural SIV hosts.
Paiardini M. Paiardini M. Curr Opin HIV AIDS. 2010 Mar;5(2):166-72. doi: 10.1097/COH.0b013e328335c161. Curr Opin HIV AIDS. 2010. PMID: 20543595 Review. - Th17 cells, HIV and the gut mucosal barrier.
Dandekar S, George MD, Bäumler AJ. Dandekar S, et al. Curr Opin HIV AIDS. 2010 Mar;5(2):173-8. doi: 10.1097/COH.0b013e328335eda3. Curr Opin HIV AIDS. 2010. PMID: 20543596 Review. - Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression.
Engram JC, Dunham RM, Makedonas G, Vanderford TH, Sumpter B, Klatt NR, Ratcliffe SJ, Garg S, Paiardini M, McQuoid M, Altman JD, Staprans SI, Betts MR, Garber DA, Feinberg MB, Silvestri G. Engram JC, et al. J Immunol. 2009 Jul 1;183(1):706-17. doi: 10.4049/jimmunol.0803746. J Immunol. 2009. PMID: 19542473 - AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Müller-Trutwin M, Hurtrel B, Lévy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J. Campillo-Gimenez L, et al. J Immunol. 2010 Jan 15;184(2):984-92. doi: 10.4049/jimmunol.0902316. Epub 2009 Dec 16. J Immunol. 2010. PMID: 20018630
Cited by
- Oncogenic role of Tc17 cells in cervical cancer development.
Zhang ZS, Gu Y, Liu BG, Tang H, Hua Y, Wang J. Zhang ZS, et al. World J Clin Cases. 2020 Jan 6;8(1):11-19. doi: 10.12998/wjcc.v8.i1.11. World J Clin Cases. 2020. PMID: 31970165 Free PMC article. - CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy.
Perdomo-Celis F, Taborda NA, Rugeles MT. Perdomo-Celis F, et al. Front Immunol. 2019 Aug 9;10:1896. doi: 10.3389/fimmu.2019.01896. eCollection 2019. Front Immunol. 2019. PMID: 31447862 Free PMC article. Review. - Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues.
Zaric M, Becker PD, Hervouet C, Kalcheva P, Doszpoly A, Blattman N, A O' Neill L, Yus BI, Cocita C, Kwon SY, Baker AH, Lord GM, Klavinskis LS. Zaric M, et al. Nat Commun. 2019 May 17;10(1):2214. doi: 10.1038/s41467-019-09969-2. Nat Commun. 2019. PMID: 31101810 Free PMC article. - Distribution of Functional CD4 and CD8 T cell Subsets in Blood and Rectal Mucosal Tissues.
Amancha PK, Ackerley CG, Duphare C, Lee M, Hu YJ, Amara RR, Kelley CF. Amancha PK, et al. Sci Rep. 2019 May 6;9(1):6951. doi: 10.1038/s41598-019-43311-6. Sci Rep. 2019. PMID: 31061442 Free PMC article. - Ectonucleotidases in Intestinal and Hepatic Inflammation.
Vuerich M, Robson SC, Longhi MS. Vuerich M, et al. Front Immunol. 2019 Mar 19;10:507. doi: 10.3389/fimmu.2019.00507. eCollection 2019. Front Immunol. 2019. PMID: 30941139 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
- P30 AI050409/AI/NIAID NIH HHS/United States
- P51 RR00165/RR/NCRR NIH HHS/United States
- R01 AI057029/AI/NIAID NIH HHS/United States
- R01 AI071852/AI/NIAID NIH HHS/United States
- R01 AI074471/AI/NIAID NIH HHS/United States
LinkOut - more resources
Full Text Sources
Research Materials