Lymphangiogenesis linked to VEGF-C from tumor-associated macrophages: accomplices to metastasis by cutaneous squamous cell carcinoma? - PubMed (original) (raw)
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doi: 10.1038/jid.2010.347.
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- PMID: 21157425
- DOI: 10.1038/jid.2010.347
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Lymphangiogenesis linked to VEGF-C from tumor-associated macrophages: accomplices to metastasis by cutaneous squamous cell carcinoma?
Martin S Kluger et al. J Invest Dermatol. 2011 Jan.
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Abstract
During wound healing, dermal macrophages secrete lymphangiogenic vascular endothelial growth factor (VEGF)-C, and lymphatic vessels transport cytokines and cells to draining lymph nodes. In this issue, Moussai et al. show that macrophages in peritumoral nonlesional skin near squamous cell carcinoma secrete prolymphangiogenic VEGF-C. Their study suggests how tumor-associated macrophages and neolymphatic vessels may coordinate metastasis starting early in cutaneous squamous cell carcinoma.
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- The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C.
Moussai D, Mitsui H, Pettersen JS, Pierson KC, Shah KR, Suárez-Fariñas M, Cardinale IR, Bluth MJ, Krueger JG, Carucci JA. Moussai D, et al. J Invest Dermatol. 2011 Jan;131(1):229-36. doi: 10.1038/jid.2010.266. Epub 2010 Sep 9. J Invest Dermatol. 2011. PMID: 20827282
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