FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias - PubMed (original) (raw)
Comparative Study
. 2010 Dec 14;75(24):2168-75.
doi: 10.1212/WNL.0b013e31820203a9.
S Rodrigo, F Semah, F Beuvon, E Landre, B Devaux, B Turak, C Mellerio, J-F Meder, F-X Roux, C Daumas-Duport, P Merlet, O Dulac, C Chiron
Affiliations
- PMID: 21172840
- DOI: 10.1212/WNL.0b013e31820203a9
Comparative Study
FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias
F Chassoux et al. Neurology. 2010.
Abstract
Objective: To determine the diagnostic accuracy and prognostic value of ¹⁸FDG-PET in a recent series of patients operated for intractable partial epilepsy associated with histologically proven Taylor-type focal cortical dysplasia (TTFCD) and negative MRI.
Methods: Of 23 consecutive patients (12 male, 7-38 years old) with negative 1.5-Tesla MRI, 10 exhibited subtle nonspecific abnormalities (e.g., unusual sulcus depth or gyral pattern) and the 13 others had strictly normal MRI. FDG-PET was analyzed both visually after coregistration on MRI and using SPM5 software. Metabolic data were compared with the epileptogenic zone (EZ) determined by stereo-EEG (SEEG) and surgical outcome.
Results: Visual PET analysis disclosed a focal or regional hypometabolism in 18 cases (78%) corresponding to a single gyrus (n = 9) or a larger cortical region (n = 9). PET/MRI coregistration detected a partially hypometabolic gyrus in 4 additional cases. SPM5 PET analysis (n = 18) was concordant with visual analysis in 13 cases. Location of PET abnormalities was extratemporal in all cases, involving eloquent cortex in 15 (65%). Correlations between SEEG, PET/MRI, and histologic findings (n = 20) demonstrated that single hypometabolic gyri (n = 11) corresponded to EZ and TTFCD, which was localized at the bottom of the sulcus. Larger hypometabolic areas (n = 9) also included the EZ and the dysplastic cortex but were more extensive. Following limited cortical resection (mean follow-up 4 years), seizure freedom without permanent motor deficit was obtained in 20/23 patients (87%).
Conclusions: ¹⁸FDG-PET coregistered with MRI is highly sensitive to detect TTFCD and greatly improves diagnosis and surgical prognosis of patients with negative MRI.
Similar articles
- [Surgical resection of focal cortical dysplasias in the central region].
Marnet D, Devaux B, Chassoux F, Landré E, Mann M, Turak B, Rodrigo S, Varlet P, Daumas-Duport C. Marnet D, et al. Neurochirurgie. 2008 May;54(3):399-408. doi: 10.1016/j.neuchi.2008.02.054. Epub 2008 Apr 18. Neurochirurgie. 2008. PMID: 18423502 French. - Type II focal cortical dysplasia: electroclinical phenotype and surgical outcome related to imaging.
Chassoux F, Landré E, Mellerio C, Turak B, Mann MW, Daumas-Duport C, Chiron C, Devaux B. Chassoux F, et al. Epilepsia. 2012 Feb;53(2):349-58. doi: 10.1111/j.1528-1167.2011.03363.x. Epub 2012 Jan 5. Epilepsia. 2012. PMID: 22221288 - PET/MRI and PET/MRI/SISCOM coregistration in the presurgical evaluation of refractory focal epilepsy.
Fernández S, Donaire A, Serès E, Setoain X, Bargalló N, Falcón C, Sanmartí F, Maestro I, Rumià J, Pintor L, Boget T, Aparicio J, Carreño M. Fernández S, et al. Epilepsy Res. 2015 Mar;111:1-9. doi: 10.1016/j.eplepsyres.2014.12.011. Epub 2015 Jan 3. Epilepsy Res. 2015. PMID: 25769367 - [Positron emission tomography: which indications, which benefits?].
Chassoux F, Chiron C. Chassoux F, et al. Neurochirurgie. 2008 May;54(3):219-25. doi: 10.1016/j.neuchi.2008.02.023. Epub 2008 Apr 21. Neurochirurgie. 2008. PMID: 18430441 Review. French. - Seizure outcome following primary motor cortex-sparing resective surgery for perirolandic focal cortical dysplasia.
Gopinath S, Roy AG, Vinayan KP, Kumar A, Sarma M, Rajeshkannan R, Pillai A. Gopinath S, et al. Int J Surg. 2016 Dec;36(Pt B):466-476. doi: 10.1016/j.ijsu.2015.10.036. Epub 2015 Nov 2. Int J Surg. 2016. PMID: 26542986 Review.
Cited by
- Hypometabolic patterns are related to post-surgical seizure outcomes in focal cortical dysplasia: A semi-quantitative study.
Yao Y, Wang X, Zhao B, Mo J, Guo Z, Yang B, Li Z, Fan X, Cai D, Sang L, Zheng Z, Shao X, Ai L, Hu W, Zhang C, Zhang K. Yao Y, et al. Epilepsia Open. 2024 Apr;9(2):653-664. doi: 10.1002/epi4.12903. Epub 2024 Jan 24. Epilepsia Open. 2024. PMID: 38265725 Free PMC article. - Multimodality Image Post-processing in Detection of Extratemporal MRI-Negative Cortical Dysplasia.
Hu WH, Wang X, Liu LN, Shao XQ, Zhang K, Ma YS, Ai L, Li JJ, Zhang JG. Hu WH, et al. Front Neurol. 2018 Jun 14;9:450. doi: 10.3389/fneur.2018.00450. eCollection 2018. Front Neurol. 2018. PMID: 29963006 Free PMC article. - The role of functional neuroimaging in pre-surgical epilepsy evaluation.
Pittau F, Grouiller F, Spinelli L, Seeck M, Michel CM, Vulliemoz S. Pittau F, et al. Front Neurol. 2014 Mar 24;5:31. doi: 10.3389/fneur.2014.00031. eCollection 2014. Front Neurol. 2014. PMID: 24715886 Free PMC article. Review. - Combination of PET and Magnetoencephalography in the Presurgical Assessment of MRI-Negative Epilepsy.
Rheims S, Jung J, Ryvlin P. Rheims S, et al. Front Neurol. 2013 Nov 21;4:188. doi: 10.3389/fneur.2013.00188. Front Neurol. 2013. PMID: 24312076 Free PMC article. Review. - Localization of the Epileptogenic Zone by Multimodal Neuroimaging and High-Frequency Oscillation.
Li X, Yu T, Ren Z, Wang X, Yan J, Chen X, Yan X, Wang W, Xing Y, Zhang X, Zhang H, Loh HH, Zhang G, Yang X. Li X, et al. Front Hum Neurosci. 2021 Jun 8;15:677840. doi: 10.3389/fnhum.2021.677840. eCollection 2021. Front Hum Neurosci. 2021. PMID: 34168546 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical