The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology - PubMed (original) (raw)
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The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology
Bryan Krock et al. Cell Metab. 2011.
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Abstract
How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.
Copyright © 2011 Elsevier Inc. All rights reserved.
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- Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
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