Long-term effect of mediterranean-style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men - PubMed (original) (raw)

Long-term effect of mediterranean-style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men

Katherine Esposito et al. Cardiol Res Pract. 2010.

Abstract

We report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of a Mediterranean dietary pattern in the overweight group (MED diet group), associated with calorie restriction and increased physical activity in the obese group (lifestyle group). Both groups were compared with participants in two matched control groups (advice groups). After 2 years, there was a significant difference in weight loss between groups, which was -14 kg (95% CI -20 to -8) in lifestyle groups and -2.0 kg (-4.4 to 0) in the advice groups, with a difference of -11.9 kg (CI -19 to -4.7 kg, P < .001); moreover, there was a significant difference between groups at 2 years for insulin (P = .04), 8-iso-PGF2α (P = .037), glucose (P = .04), and adiponectin (P = .01). Prolonged adherence to a Mediterranean-style diet, with or without caloric restriction, in overweight or obese men is associated with significant amelioration of multiple risk factors, including a better cardiovascular risk profile, reduced oxidative stress, and improved insulin sensitivity.

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Figures

Figure 1

Figure 1

Changes in fasting plasma total cholesterol, glucose, insulin, mean blood pressure, insulin, adiponectin, and 8-iso-PGF2_α_ levels at year 1 and year 2 in subjects of intervention groups (black columns: lifestyle, white columns: MED diet). All parameters represent the net effect (intervention group, advice group) of treatments and were significantly reduced from baseline values at year 1 and year 2 in both groups.

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