Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes - PubMed (original) (raw)
Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes
D L Cheung et al. Immunology. 1990 Sep.
Abstract
Stimulated human monocytes/macrophages are a source of interleukin-6 (IL-6), which is a likely mediator involved in immune and inflammatory reactions. The means to control production of IL-6 by these cells could therefore have therapeutic applications. We report here, for lipopolysaccharide (LPS)-stimulated human monocytes in vitro, that the lymphokine, interferon-gamma (IFN-gamma) (100 U/ml), enhanced the level of IL-6 activity, whereas another lymphokine, interleukin-4 (IL-4) (greater than or equal to 0.1 U/ml; greater than or equal to 1.2 x 10(-11) M), suppressed it. The effects of the two lymphokines were manifested at the level of mRNA. The action of the IL-4 was similar to that of the glucocorticoid, dexamethasone, but observed at a lower molar concentration. Such regulation of monocyte IL-6 activity is similar to that found previously for interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-alpha) synthesis.
Similar articles
- Interleukin-4 suppresses granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor levels in stimulated human monocytes.
Hamilton JA, Whitty GA, Royston AK, Cebon J, Layton JE. Hamilton JA, et al. Immunology. 1992 Aug;76(4):566-71. Immunology. 1992. PMID: 1383133 Free PMC article. - Control by IFN-gamma and PGE2 of TNF alpha and IL-1 production by human monocytes.
Hart PH, Whitty GA, Piccoli DS, Hamilton JA. Hart PH, et al. Immunology. 1989 Mar;66(3):376-83. Immunology. 1989. PMID: 2495247 Free PMC article. - Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis.
Wanidworanun C, Strober W. Wanidworanun C, et al. J Immunol. 1993 Dec 15;151(12):6853-61. J Immunol. 1993. PMID: 8258695 - Differential responses of human monocytes and macrophages to IL-4 and IL-13.
Hart PH, Bonder CS, Balogh J, Dickensheets HL, Donnelly RP, Finlay-Jones JJ. Hart PH, et al. J Leukoc Biol. 1999 Oct;66(4):575-8. J Leukoc Biol. 1999. PMID: 10534111 Review.
Cited by
- Cannabidiol (CBD) Protects Adipose-Derived Mesenchymal Stem Cells (ASCs) against Endoplasmic Reticulum Stress Development and Its Complications.
Kowalczuk A, Marycz K, Kornicka-Garbowska K, Kornicka J, Bujalska-Zadrożny M, Groborz S. Kowalczuk A, et al. Int J Environ Res Public Health. 2022 Aug 31;19(17):10864. doi: 10.3390/ijerph191710864. Int J Environ Res Public Health. 2022. PMID: 36078578 Free PMC article. - BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism.
Morrone MDS, Somensi N, Franz L, Ramos VM, Gasparotto J, da Rosa HT, Sartori M, Figueiró F, Gelain DP, Zanotto-Filho A, Moreira JCF. Morrone MDS, et al. Mol Cell Biochem. 2019 Dec;462(1-2):11-23. doi: 10.1007/s11010-019-03605-9. Epub 2019 Aug 24. Mol Cell Biochem. 2019. PMID: 31446616 - Mechanism of Interleukin-4 Reducing Lipid Deposit by Regulating Hormone-Sensitive Lipase.
Shiau MY, Chuang PH, Yang CP, Hsiao CW, Chang SW, Chang KY, Liu TM, Chen HW, Chuang CC, Yuan SY, Chang YH. Shiau MY, et al. Sci Rep. 2019 Aug 19;9(1):11974. doi: 10.1038/s41598-019-47908-9. Sci Rep. 2019. PMID: 31427606 Free PMC article. - Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase.
Zanin RF, Braganhol E, Bergamin LS, Campesato LF, Filho AZ, Moreira JC, Morrone FB, Sévigny J, Schetinger MR, de Souza Wyse AT, Battastini AM. Zanin RF, et al. PLoS One. 2012;7(2):e31205. doi: 10.1371/journal.pone.0031205. Epub 2012 Feb 13. PLoS One. 2012. PMID: 22348056 Free PMC article. - Influence of liver cancer on lipid and lipoprotein metabolism.
Jiang J, Nilsson-Ehle P, Xu N. Jiang J, et al. Lipids Health Dis. 2006 Mar 3;5:4. doi: 10.1186/1476-511X-5-4. Lipids Health Dis. 2006. PMID: 16515689 Free PMC article. Review.
References
- Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
- J Immunol. 1988 Sep 1;141(5):1529-35 - PubMed
- J Immunol Methods. 1984 Mar 16;67(2):379-88 - PubMed
- J Immunol. 1986 Feb 1;136(3):949-54 - PubMed
- Blood. 1988 Oct;72(4):1134-40 - PubMed