Perspective: alpha-bugs, their microbial partners, and the link to colon cancer - PubMed (original) (raw)

Cynthia L Sears et al. J Infect Dis. 2011.

No abstract available

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Figures

Figure 1.

Figure 1.

Tripartite relationship contributing to colon cancer pathogenesis. The microbiome, colonic mucosal immune balance, and colonic epithelial cell (CEC) responses (to the microbiome and mucosal immune responses) and CEC genetics are proposed to collectively contribute to the pathogenesis of colon cancer.

Figure 2.

Figure 2.

Model of colon cancer induction by Alpha-bugs. The model uses data on enterotoxigenic Bacteroidesfragilis (ETBF) as an example of a putative Alpha-bug. Detailed description of the model is contained in the text. Abbreviations: ROS = reactive oxygen species; NOS = nitric oxide synthase.

Figure 3.

Figure 3.

Enterotoxigenic Bacteroides fragilis (ETBF)–induced colon tumors in multiple intestinal neoplasia (Min) mice. Colons from Min mice colonized with ETBF or nontoxigenic B. fragilis (NTBF) or sham-inoculated mice for one or 3 months are shown. Colons are stained with methylene blue to facilitate enumeration of colon tumors by dissecting microscope examination. The number of colon tumors identified in each depicted mouse colon is shown in parentheses.

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