The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade - PubMed (original) (raw)

The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade

Xiao-Feng Le et al. Cancer Microenviron. 2010.

Abstract

Cancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in the circulation; 5) extravasation into distant organs; and 6) colonization and growth of metastatic tumors. microRNAs (miRNAs) play critical roles in this multi-step process, both promoting and suppressing metastasis. This review updates the progress made in understanding the roles of miRNAs for invasion and metastasis during cancer progression. A specific miRNA signature of cancer metastasis is also reviewed.

Keywords: Cancer metastasis; Cancer stem cells and angiogenesis; Invasion; miRNAs.

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Figures

Fig. 1

A network of microRNAs and protein-coding genes involved in the multiple steps of cancer metastasis. For details see text

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