HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF - PubMed (original) (raw)
. 2011 Jan 18;19(1):31-44.
doi: 10.1016/j.ccr.2010.11.009. Epub 2011 Jan 6.
Massimiliano Mazzone, Sònia Tugues, Damya Laoui, Irja Johansson, Cathy Coulon, Mario Leonardo Squadrito, Inmaculada Segura, Xiujuan Li, Ellen Knevels, Sandra Costa, Stefan Vinckier, Tom Dresselaer, Peter Åkerud, Maria De Mol, Henriikka Salomäki, Mia Phillipson, Sabine Wyns, Erik Larsson, Ian Buysschaert, Johan Botling, Uwe Himmelreich, Jo A Van Ginderachter, Michele De Palma, Mieke Dewerchin, Lena Claesson-Welsh, Peter Carmeliet
Affiliations
- PMID: 21215706
- DOI: 10.1016/j.ccr.2010.11.009
Free article
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF
Charlotte Rolny et al. Cancer Cell. 2011.
Free article
Abstract
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polarization away from the M2- to a tumor-inhibiting M1-like phenotype, HRG promotes antitumor immune responses and vessel normalization, effects known to decrease tumor growth and metastasis and to enhance chemotherapy. Skewing of TAM polarization by HRG relies substantially on downregulation of placental growth factor (PlGF). Besides unveiling an important role for TAM polarization in tumor vessel abnormalization, and its regulation by HRG/PlGF, these findings offer therapeutic opportunities for anticancer and antiangiogenic treatment.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment in
- Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Huang Y, Snuderl M, Jain RK. Huang Y, et al. Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005. Cancer Cell. 2011. PMID: 21251607 Free PMC article. - Cancer: Re-educating tumour-associated macrophages.
Flemming A. Flemming A. Nat Rev Drug Discov. 2011 Mar;10(3):177. doi: 10.1038/nrd3399. Nat Rev Drug Discov. 2011. PMID: 21358735 No abstract available.
Similar articles
- Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization.
Tugues S, Honjo S, König C, Noguer O, Hedlund M, Botling J, Deschoemaeker S, Wenes M, Rolny C, Jahnen-Dechent W, Mazzone M, Claesson-Welsh L. Tugues S, et al. Cancer Res. 2012 Apr 15;72(8):1953-63. doi: 10.1158/0008-5472.CAN-11-2194. Epub 2012 Feb 28. Cancer Res. 2012. PMID: 22374984 - The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis.
Li GG, Guo ZZ, Ma XF, Cao N, Geng SN, Zheng YQ, Meng MJ, Lin HH, Han G, Du GJ. Li GG, et al. Dev Comp Immunol. 2016 Jun;59:89-98. doi: 10.1016/j.dci.2016.01.010. Epub 2016 Jan 22. Dev Comp Immunol. 2016. PMID: 26806760 - Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.
Palmieri EM, Menga A, Martín-Pérez R, Quinto A, Riera-Domingo C, De Tullio G, Hooper DC, Lamers WH, Ghesquière B, McVicar DW, Guarini A, Mazzone M, Castegna A. Palmieri EM, et al. Cell Rep. 2017 Aug 15;20(7):1654-1666. doi: 10.1016/j.celrep.2017.07.054. Cell Rep. 2017. PMID: 28813676 Free PMC article. - Role of macrophage polarization in tumor angiogenesis and vessel normalization: implications for new anticancer therapies.
Chen P, Bonaldo P. Chen P, et al. Int Rev Cell Mol Biol. 2013;301:1-35. doi: 10.1016/B978-0-12-407704-1.00001-4. Int Rev Cell Mol Biol. 2013. PMID: 23317816 Review. - The roles of tumor-associated macrophages in tumor angiogenesis and metastasis.
Fu LQ, Du WL, Cai MH, Yao JY, Zhao YY, Mou XZ. Fu LQ, et al. Cell Immunol. 2020 Jul;353:104119. doi: 10.1016/j.cellimm.2020.104119. Epub 2020 May 4. Cell Immunol. 2020. PMID: 32446032 Review.
Cited by
- Manganese boosts natural killer cell function via cGAS-STING mediated UTX expression.
Ming Q, Liu J, Lv Z, Wang T, Fan R, Zhang Y, Chen M, Sun Y, Han W, Mei Q. Ming Q, et al. MedComm (2020). 2024 Aug 28;5(9):e683. doi: 10.1002/mco2.683. eCollection 2024 Sep. MedComm (2020). 2024. PMID: 39206412 Free PMC article. - The complex role of macrophages in pancreatic cancer tumor microenvironment: a review on cancer progression and potential therapeutic targets.
Lorestani P, Dashti M, Nejati N, Habibi MA, Askari M, Robat-Jazi B, Ahmadpour S, Tavakolpour S. Lorestani P, et al. Discov Oncol. 2024 Aug 26;15(1):369. doi: 10.1007/s12672-024-01256-x. Discov Oncol. 2024. PMID: 39186144 Free PMC article. Review. - Overcoming treatment resistance in cholangiocarcinoma: current strategies, challenges, and prospects.
Wang J, Liu S, Cao Y, Chen Y. Wang J, et al. Front Cell Dev Biol. 2024 Aug 2;12:1408852. doi: 10.3389/fcell.2024.1408852. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39156971 Free PMC article. Review. - Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy.
Mpekris F, Panagi M, Charalambous A, Voutouri C, Stylianopoulos T. Mpekris F, et al. Cell Rep Med. 2024 Jul 16;5(7):101626. doi: 10.1016/j.xcrm.2024.101626. Epub 2024 Jun 28. Cell Rep Med. 2024. PMID: 38944037 Free PMC article. Review. - Fas Ligand enhances vessel maturation and inhibits vascular leakage associated with age-related macular degeneration.
Koirala A, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M. Koirala A, et al. Res Sq [Preprint]. 2024 May 8:rs.3.rs-4331250. doi: 10.21203/rs.3.rs-4331250/v1. Res Sq. 2024. PMID: 38766158 Free PMC article. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous