Extensive linkage disequilibrium in the achaete-scute complex of Drosophila melanogaster - PubMed (original) (raw)
Extensive linkage disequilibrium in the achaete-scute complex of Drosophila melanogaster
J N Macpherson et al. Genetics. 1990 Sep.
Abstract
We have analyzed the level of gametic association between restriction map variants in a sample of 44 X chromosomes from a natural population of Drosophila melanogaster. Of 21 pairwise tests involving 7 restriction map polymorphisms in the yellow-achaete-scute complex, 17 were found to be significant, including some between restriction sites over 80 kb apart. Three-way linkage disequilibria and their variances were also estimated for all 35 three-way comparisons between these loci. Twelve such tests were found to be significant, again spanning distances of up to 80 kb on the restriction map. Only 9 of a possible 128 haplotypes were represented in the sample and 8 of these could be linked together by changes at a single site. The strength of these associations at y-ac-sc is unusual by comparison with studies on other regions of the genome of D. melanogaster, and is consistent with the very low level of recombination which has been reported for the complex. However, our estimate of nucleotide diversity in the region is not significantly different from those made for some other loci in this species.
Similar articles
- Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster.
Aguade M, Miyashita N, Langley CH. Aguade M, et al. Genetics. 1989 Jul;122(3):607-15. doi: 10.1093/genetics/122.3.607. Genetics. 1989. PMID: 17246506 Free PMC article. - Restriction-map variation with the yellow-achaete-scute region in five populations of Drosophila melanogaster.
Eanes WF, Labate J, Ajioka JW. Eanes WF, et al. Mol Biol Evol. 1989 Sep;6(5):492-502. doi: 10.1093/oxfordjournals.molbev.a040565. Mol Biol Evol. 1989. PMID: 2552253 - On the detection of nonrandom associations between DNA polymorphisms in natural populations of Drosophila.
Zapata C, Alvarez G. Zapata C, et al. Mol Biol Evol. 1993 Jul;10(4):823-41. doi: 10.1093/oxfordjournals.molbev.a040045. Mol Biol Evol. 1993. PMID: 8355602 - Patterns of naturally occurring restriction map variation, dopa decarboxylase activity variation and linkage disequilibrium in the Ddc gene region of Drosophila melanogaster.
Aquadro CF, Jennings RM Jr, Bland MM, Laurie CC, Langley CH. Aquadro CF, et al. Genetics. 1992 Oct;132(2):443-52. doi: 10.1093/genetics/132.2.443. Genetics. 1992. PMID: 1358752 Free PMC article. - Mitochondrial DNA in the Drosophila melanogaster complex.
Solignac M. Solignac M. Genetica. 2004 Mar;120(1-3):41-50. doi: 10.1023/b:gene.0000017628.52056.97. Genetica. 2004. PMID: 15088645 Review.
Cited by
- Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster.
Michalak P, Kang L, Sarup PM, Schou MF, Loeschcke V. Michalak P, et al. BMC Genomics. 2017 Jan 14;18(1):84. doi: 10.1186/s12864-017-3485-0. BMC Genomics. 2017. PMID: 28088192 Free PMC article. - Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes.
Takano-Shimizu T, Kawabe A, Inomata N, Nanba N, Kondo R, Inoue Y, Itoh M. Takano-Shimizu T, et al. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14156-61. doi: 10.1073/pnas.0401782101. Epub 2004 Sep 17. Proc Natl Acad Sci U S A. 2004. PMID: 15377795 Free PMC article. - Two-locus sampling distributions and their application.
Hudson RR. Hudson RR. Genetics. 2001 Dec;159(4):1805-17. doi: 10.1093/genetics/159.4.1805. Genetics. 2001. PMID: 11779816 Free PMC article. - A test of neutrality based on interlocus associations.
Kelly JK. Kelly JK. Genetics. 1997 Jul;146(3):1197-206. doi: 10.1093/genetics/146.3.1197. Genetics. 1997. PMID: 9215920 Free PMC article. - Genome-wide high-resolution mapping by recurrent intermating using Arabidopsis thaliana as a model.
Liu SC, Kowalski SP, Lan TH, Feldmann KA, Paterson AH. Liu SC, et al. Genetics. 1996 Jan;142(1):247-58. doi: 10.1093/genetics/142.1.247. Genetics. 1996. PMID: 8770602 Free PMC article.
References
- Genet Res. 1974 Feb;23(1):23-35 - PubMed
- Genetics. 1988 Aug;119(4):829-62 - PubMed
- Proc Natl Acad Sci U S A. 1983 Sep;80(17):5350-4 - PubMed
- Tissue Antigens. 1984 Oct;24(4):250-5 - PubMed
- EMBO J. 1982;1(10):1185-91 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Molecular Biology Databases