Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila - PubMed (original) (raw)
. 2011 Jan 21;144(2):214-26.
doi: 10.1016/j.cell.2010.12.026.
Affiliations
- PMID: 21241892
- DOI: 10.1016/j.cell.2010.12.026
Free article
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
Frédéric Bantignies et al. Cell. 2011.
Free article
Abstract
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of the two Hox complexes can interact within nuclear PcG bodies in tissues where they are corepressed. This colocalization increases during development and depends on PcG proteins. Hox gene contacts are conserved in the distantly related Drosophila virilis species and they are part of a large gene interaction network that includes other PcG target genes. Importantly, mutations on one of the loci weaken silencing of genes in the other locus, resulting in the exacerbation of homeotic phenotypes in sensitized genetic backgrounds. Thus, the three-dimensional organization of Polycomb target genes in the cell nucleus stabilizes the maintenance of epigenetic gene silencing.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment in
- Are polycomb group bodies gene silencing factories?
Hodgson JW, Brock HW. Hodgson JW, et al. Cell. 2011 Jan 21;144(2):170-1. doi: 10.1016/j.cell.2011.01.006. Cell. 2011. PMID: 21241887 - Gene regulation: Grouped in silence.
Casci T. Casci T. Nat Rev Genet. 2011 Mar;12(3):154. doi: 10.1038/nrg2963. Nat Rev Genet. 2011. PMID: 21331087 No abstract available.
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