Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia - PubMed (original) (raw)

. 2011 Jan 18;19(1):138-52.

doi: 10.1016/j.ccr.2010.12.012.

Emanuele Marchi, Ann Atzberger, Lynn Quek, Anna Schuh, Shamit Soneji, Petter Woll, Adam Mead, Kate A Alford, Raj Rout, Salma Chaudhury, Amanda Gilkes, Steve Knapper, Kheira Beldjord, Suriya Begum, Susan Rose, Nicola Geddes, Mike Griffiths, Graham Standen, Alexander Sternberg, Jamie Cavenagh, Hannah Hunter, David Bowen, Sally Killick, Lisa Robinson, Andrew Price, Elizabeth Macintyre, Paul Virgo, Alan Burnett, Charles Craddock, Tariq Enver, Sten Eirik W Jacobsen, Catherine Porcher, Paresh Vyas

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Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia

Nicolas Goardon et al. Cancer Cell. 2011.

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Abstract

The relationships between normal and leukemic stem/progenitor cells are unclear. We show that in ∼80% of primary human CD34+ acute myeloid leukemia (AML), two expanded populations with hemopoietic progenitor immunophenotype coexist in most patients. Both populations have leukemic stem cell (LSC) activity and are hierarchically ordered; one LSC population gives rise to the other. Global gene expression profiling shows the LSC populations are molecularly distinct and resemble normal progenitors but not stem cells. The more mature LSC population most closely mirrors normal granulocyte-macrophage progenitors (GMP) and the immature LSC population a previously uncharacterized progenitor functionally similar to lymphoid-primed multipotential progenitors (LMPPs). This suggests that in most cases primary CD34+ AML is a progenitor disease where LSCs acquire abnormal self-renewal potential.

Copyright © 2011 Elsevier Inc. All rights reserved.

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