A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response - PubMed (original) (raw)

. 2011 Mar 11;331(6022):1319-21.

doi: 10.1126/science.1200120. Epub 2011 Jan 20.

Goran Lakisic, Viviana Job, Lauriane Fritsch, To Nam Tham, Ana Camejo, Pierre-Jean Matteï, Béatrice Regnault, Marie-Anne Nahori, Didier Cabanes, Alexis Gautreau, Slimane Ait-Si-Ali, Andréa Dessen, Pascale Cossart, Hélène Bierne

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A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response

Alice Lebreton et al. Science. 2011.

Abstract

Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host.

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