Searching for synthetic lethality in cancer - PubMed (original) (raw)
Review
Searching for synthetic lethality in cancer
Rachel Brough et al. Curr Opin Genet Dev. 2011 Feb.
Abstract
The incentive to develop personalised therapy for cancer treatment is driven by the premise that it will increase therapeutic efficacy and reduce toxicity. Understanding the underlying cellular and molecular basis of the disease has been extremely important in the design of these novel therapies; however, identifying new drug targets for personalised therapies remains problematic. This review describes how the biological concept of synthetic lethality has been successfully implemented to identify new therapeutic approaches and targets in models from yeast through to human cells. We also discuss how recent technical advances combined with an increased understanding of the complexity of cellular networks may facilitate therapeutic advances in the future.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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