Efficacy of ampicillin versus trimethoprim-sulfamethoxazole in a mouse model of lethal enterococcal peritonitis - PubMed (original) (raw)

Comparative Study

Efficacy of ampicillin versus trimethoprim-sulfamethoxazole in a mouse model of lethal enterococcal peritonitis

C E Chenoweth et al. Antimicrob Agents Chemother. 1990 Sep.

Abstract

Lethal enterococcal peritonitis in mice was used to compare trimethoprim-sulfamethoxazole (TMP-SMX) therapy with ampicillin therapy. Peritoneal fluid showed a 10(3)-CFU decrease in enterococci with ampicillin compared with TMP-SMX. Mortality of the untreated mice was 100%, compared with 40% for ampicillin and 95% for TMP-SMX, despite adequately measured levels in serum and peritoneal fluid.

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References

    1. JAMA. 1984 Nov 16;252(19):2748-9 -PubMed
    1. Antimicrob Agents Chemother. 1985 Jan;27(1):71-5 -PubMed
    1. Antimicrob Agents Chemother. 1985 Sep;28(3):446-8 -PubMed
    1. Antimicrob Agents Chemother. 1986 Dec;30(6):861-4 -PubMed
    1. Ann Intern Med. 1987 May;106(5):687-91 -PubMed

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