Biological and clinical aspects of interleukin 6 - PubMed (original) (raw)
Review
Biological and clinical aspects of interleukin 6
T Hirano et al. Immunol Today. 1990 Dec.
Abstract
Interleukin 6 (IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.
Comment in
- Further functions of IL-6.
Hopkins SJ, Rothwell NJ. Hopkins SJ, et al. Immunol Today. 1991 May;12(5):170. doi: 10.1016/S0167-5699(05)80050-7. Immunol Today. 1991. PMID: 1750926 No abstract available.
Similar articles
- The evidence for interleukin-6 as an autocrine growth factor in malignancy.
Akira S, Kishimoto T. Akira S, et al. Semin Cancer Biol. 1992 Feb;3(1):17-26. Semin Cancer Biol. 1992. PMID: 1643291 Review. - Interleukin 6 (IL-6) and its receptor: their role in plasma cell neoplasias.
Hirano T. Hirano T. Int J Cell Cloning. 1991 May;9(3):166-84. doi: 10.1002/stem.5530090303. Int J Cell Cloning. 1991. PMID: 2061619 Review. - Interleukin-6 and its relation to inflammation and disease.
Hirano T. Hirano T. Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S60-5. doi: 10.1016/0090-1229(92)90042-m. Clin Immunol Immunopathol. 1992. PMID: 1728989 Review. - Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma.
Suematsu S, Hibi M, Sugita T, Saito M, Murakami M, Matsusaka T, Matsuda T, Hirano T, Taga T, Kishimoto T. Suematsu S, et al. Curr Top Microbiol Immunol. 1990;166:13-22. doi: 10.1007/978-3-642-75889-8_2. Curr Top Microbiol Immunol. 1990. PMID: 2073791 Review. No abstract available. - Interleukin-6 in autoimmune disorders.
Yoshizaki K, Kuritani T, Kishimoto T. Yoshizaki K, et al. Semin Immunol. 1992 Jun;4(3):155-66. Semin Immunol. 1992. PMID: 1627787 Review.
Cited by
- Interleukin-6 serum level and monocyte production in head and neck cancer.
Gallo O, Gori AM, Attanasio M, Martini F, Fini-Storchi O, Abbate R. Gallo O, et al. Br J Cancer. 1992 Mar;65(3):479-80. doi: 10.1038/bjc.1992.97. Br J Cancer. 1992. PMID: 1558807 Free PMC article. No abstract available. - Etiology of Paget's disease of bone: a new perspective.
Bataille R, Klein B. Bataille R, et al. Calcif Tissue Int. 1992 Mar;50(3):293-4. doi: 10.1007/BF00296296. Calcif Tissue Int. 1992. PMID: 1617506 No abstract available. - Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites.
Francés R, Muñoz C, Zapater P, Uceda F, Gascón I, Pascual S, Pérez-Mateo M, Such J. Francés R, et al. Gut. 2004 Jun;53(6):860-4. doi: 10.1136/gut.2003.027425. Gut. 2004. PMID: 15138214 Free PMC article. - miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB.
Xu Z, Xiao SB, Xu P, Xie Q, Cao L, Wang D, Luo R, Zhong Y, Chen HC, Fang LR. Xu Z, et al. J Biol Chem. 2011 Jun 17;286(24):21401-12. doi: 10.1074/jbc.M110.198630. Epub 2011 Apr 25. J Biol Chem. 2011. PMID: 21518763 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources