Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes - PubMed (original) (raw)
Comparative Study
. 2011 Feb 10;69(3):445-52.
doi: 10.1016/j.neuron.2010.12.038.
Affiliations
- PMID: 21315256
- DOI: 10.1016/j.neuron.2010.12.038
Free article
Comparative Study
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes
Jing Ren et al. Neuron. 2011.
Free article
Abstract
Acetylcholine is an important neurotransmitter, and the habenulo-interpeduncular projection is a major cholinergic pathway in the brain. To study the physiological properties of cholinergic transmission in the interpeduncular nucleus (IPN), we used a transgenic mouse line in which the light-gated cation channel ChannelRhodopsin-2 is selectively expressed in cholinergic neurons. Cholinergic axonal terminals were activated by light pulses, and postsynaptic responses were recorded from IPN neurons. Surprisingly, brief photostimulation produces fast excitatory postsynaptic currents that are mediated by ionotropic glutamate receptors, suggesting wired transmission of glutamate. By contrast, tetanic photostimulation generates slow inward currents that are largely mediated by nicotinic acetylcholine receptors, suggesting volume transmission of acetylcholine. Finally, vesicular transporters for glutamate and acetylcholine are coexpressed on the same axonal terminals in the IPN. These results strongly suggest that adult brain "cholinergic" neurons can corelease glutamate and acetylcholine, but these two neurotransmitters activate postsynaptic neurons via different transmission modes.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
- Muscarinic and nicotinic presynaptic modulation of EPSCs in the nucleus accumbens during postnatal development.
Zhang L, Warren RA. Zhang L, et al. J Neurophysiol. 2002 Dec;88(6):3315-30. doi: 10.1152/jn.01025.2001. J Neurophysiol. 2002. PMID: 12466449 - Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Saunders A, Granger AJ, Sabatini BL. Saunders A, et al. Elife. 2015 Feb 27;4:e06412. doi: 10.7554/eLife.06412. Elife. 2015. PMID: 25723967 Free PMC article. - Frog retinal ganglion cells projecting to the tectum layer F release acetylcholine as co-mediator.
Baginskas A, Kuraite V, Kuras A. Baginskas A, et al. Neurosci Lett. 2012 Aug 1;522(2):145-50. doi: 10.1016/j.neulet.2012.06.028. Epub 2012 Jun 19. Neurosci Lett. 2012. PMID: 22728061 - Modulation of sensory input to the spinal cord by presynaptic ionotropic glutamate receptors.
Rustioni A. Rustioni A. Arch Ital Biol. 2005 May;143(2):103-12. Arch Ital Biol. 2005. PMID: 16106991 Review. - Mechanisms of excitatory synaptic transmission in the enteric nervous system.
Galligan JJ. Galligan JJ. Tokai J Exp Clin Med. 1998 Jun;23(3):129-36. Tokai J Exp Clin Med. 1998. PMID: 9972540 Review.
Cited by
- Visualization and manipulation of neural activity in the developing vertebrate nervous system.
Zhang J, Ackman JB, Dhande OS, Crair MC. Zhang J, et al. Front Mol Neurosci. 2011 Nov 18;4:43. doi: 10.3389/fnmol.2011.00043. eCollection 2011. Front Mol Neurosci. 2011. PMID: 22121343 Free PMC article. - Optogenetic Control of Cardiac Autonomic Neurons in Transgenic Mice.
Moreno A, Kowalik G, Mendelowitz D, Kay MW. Moreno A, et al. Methods Mol Biol. 2021;2191:309-321. doi: 10.1007/978-1-0716-0830-2_18. Methods Mol Biol. 2021. PMID: 32865752 Free PMC article. - Comparative transcriptomics reveals highly conserved regional programs between porcine and human colonic enteric nervous system.
Li T, Morselli M, Su T, Million M, Larauche M, Pellegrini M, Taché Y, Yuan PQ. Li T, et al. Commun Biol. 2023 Jan 24;6(1):98. doi: 10.1038/s42003-023-04478-x. Commun Biol. 2023. PMID: 36693960 Free PMC article. - Understanding the habenula: A major node in circuits regulating emotion and motivation.
Ables JL, Park K, Ibañez-Tallon I. Ables JL, et al. Pharmacol Res. 2023 Apr;190:106734. doi: 10.1016/j.phrs.2023.106734. Epub 2023 Mar 16. Pharmacol Res. 2023. PMID: 36933754 Free PMC article. Review. - Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration.
Souter EA, Chen YC, Zell V, Lallai V, Steinkellner T, Conrad WS, Wisden W, Harris KD, Fowler CD, Hnasko TS. Souter EA, et al. eNeuro. 2022 Jan 10;9(1):ENEURO.0481-21.2021. doi: 10.1523/ENEURO.0481-21.2021. Print 2022 Jan-Feb. eNeuro. 2022. PMID: 34876472 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases