Trophectoderm lineage determination in cattle - PubMed (original) (raw)
Trophectoderm lineage determination in cattle
Debra K Berg et al. Dev Cell. 2011.
Free article
Abstract
The trophectoderm (TE) and inner cell mass (ICM) are committed and marked by reciprocal expression of Cdx2 and Oct4 in mouse late blastocysts. We find that the TE is not committed at equivalent stages in cattle, and that bovine Cdx2 is required later, for TE maintenance, but does not repress Oct4 expression. A mouse Oct4 (mOct4) reporter, repressed in mouse TE, remained active in the cattle TE; bovine Oct4 constructs were not repressed in the mouse TE. mOct4 has acquired Tcfap2 binding sites mediating Cdx2-independent repression-cattle, humans, and rabbits do not contain these sites and maintain high Oct4 levels in the TE. Our data suggest that the regulatory circuitry determining ICM/TE identity has been rewired in mice, to allow rapid TE differentiation and early blastocyst implantation. These findings thus emphasize ways in which mice may not be representative of the earliest stages of mammalian development and stem cell biology.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
- CDX2 regulates multiple trophoblast genes in bovine trophectoderm CT-1 cells.
Schiffmacher AT, Keefer CL. Schiffmacher AT, et al. Mol Reprod Dev. 2013 Oct;80(10):826-39. doi: 10.1002/mrd.22212. Epub 2013 Aug 30. Mol Reprod Dev. 2013. PMID: 23836438 - Aberrant expression patterns of genes involved in segregation of inner cell mass and trophectoderm lineages in bovine embryos derived from somatic cell nuclear transfer.
Fujii T, Moriyasu S, Hirayama H, Hashizume T, Sawai K. Fujii T, et al. Cell Reprogram. 2010 Oct;12(5):617-25. doi: 10.1089/cell.2010.0017. Cell Reprogram. 2010. PMID: 20726774 - Roles of ERα during mouse trophectoderm lineage differentiation: revealed by antagonist and agonist of ERα.
Cheng X, Xu S, Song C, He L, Lian X, Liu Y, Wei J, Pang L, Wang S. Cheng X, et al. Dev Growth Differ. 2016 Apr;58(3):327-38. doi: 10.1111/dgd.12276. Epub 2016 Apr 1. Dev Growth Differ. 2016. PMID: 27037955 - Mechanisms of trophectoderm fate specification in preimplantation mouse development.
Sasaki H. Sasaki H. Dev Growth Differ. 2010 Apr;52(3):263-73. doi: 10.1111/j.1440-169X.2009.01158.x. Epub 2010 Jan 20. Dev Growth Differ. 2010. PMID: 20100249 Review. - Establishment of trophectoderm and inner cell mass lineages in the mouse embryo.
Marikawa Y, Alarcón VB. Marikawa Y, et al. Mol Reprod Dev. 2009 Nov;76(11):1019-32. doi: 10.1002/mrd.21057. Mol Reprod Dev. 2009. PMID: 19479991 Free PMC article. Review.
Cited by
- Combined Exogenous Activation of Bovine Oocytes: Effects on Maturation-Promoting Factor, Mitogen-Activated Protein Kinases, and Embryonic Competence.
Valencia C, Pérez-García F, Aguila L, Felmer R, Arias ME. Valencia C, et al. Int J Mol Sci. 2023 Oct 31;24(21):15794. doi: 10.3390/ijms242115794. Int J Mol Sci. 2023. PMID: 37958778 Free PMC article. - Versatile generation of precise gene edits in bovines using SEGCPN.
Wang M, Ding F, Wang H, Li L, Dai Y, Sun Z, Li N. Wang M, et al. BMC Biol. 2023 Oct 20;21(1):226. doi: 10.1186/s12915-023-01677-0. BMC Biol. 2023. PMID: 37864194 Free PMC article. - Lab partners: oocytes, embryos and company. A personal view on aspects of oocyte maturation and the development of monozygotic twins.
Meinecke B, Meinecke-Tillmann S. Meinecke B, et al. Anim Reprod. 2023 Jul 24;20(2):e20230049. doi: 10.1590/1984-3143-AR2023-0049. eCollection 2023. Anim Reprod. 2023. PMID: 37547564 Free PMC article. - In Vitro-Produced Equine Blastocysts Exhibit Greater Dispersal and Intermingling of Inner Cell Mass Cells than In Vivo Embryos.
Umair M, Scheeren VFDC, Beitsma MM, Colleoni S, Galli C, Lazzari G, de Ruijter-Villani M, Stout TAE, Claes A. Umair M, et al. Int J Mol Sci. 2023 Jun 1;24(11):9619. doi: 10.3390/ijms24119619. Int J Mol Sci. 2023. PMID: 37298570 Free PMC article. - Establishment of bovine trophoblast stem cells.
Wang Y, Ming H, Yu L, Li J, Zhu L, Sun HX, Pinzon-Arteaga CA, Wu J, Jiang Z. Wang Y, et al. Cell Rep. 2023 May 30;42(5):112439. doi: 10.1016/j.celrep.2023.112439. Epub 2023 May 4. Cell Rep. 2023. PMID: 37146606 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources