Epigenetic inheritance: uncontested? - PubMed (original) (raw)

Review

Epigenetic inheritance: uncontested?

Bing Zhu et al. Cell Res. 2011 Mar.

Abstract

"Epigenetics" is currently defined as "the inheritance of variation (-genetics) above and beyond (epi-) changes in the DNA sequence". Despite the fact that histones are believed to carry important epigenetic information, little is known about the molecular mechanisms of the inheritance of histone-based epigenetic information, including histone modifications and histone variants. Here we review recent progress and discuss potential models for the mitotic inheritance of histone modifications-based epigenetic information.

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Figures

Figure 1

Semi-conservative partition, followed by templated modification copying events: an imperfect “ideal” model. (A) Model illustration for the inheritance mechanism of DNA methylation. (B) The “ideal” but recently proven incorrect model for the inheritance of histone modifications.

Figure 2

Modification spreading model that can also be involved in the epigenetic inheritance of histone modifications.

Figure 3

A reinforcement model for epigenetic inheritance. See text for details.

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